{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:42:21Z","timestamp":1777930941741,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["OD011089"],"award-info":[{"award-number":["OD011089"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    An 11-y-old male lionhead rabbit (\n                    <jats:italic toggle=\"yes\">Oryctolagus cuniculus<\/jats:italic>\n                    ) was presented with progressive hindlimb weakness and right-sided neurologic deficits, and was subsequently euthanized due to poor prognosis. Autopsy revealed a 1.6\u2009\u00d7\u20091.1\u2009\u00d7\u20091.0-cm, well-circumscribed, extra-axial mass compressing the occipital lobe and affecting both telencephalic hemispheres. Histologic and immunohistochemical analyses demonstrating positivity for synaptophysin and neuron-specific enolase, along with a Ki67 proliferative index of ~20%, were highly suggestive of a high-grade pineal parenchymal tumor (PPT). The tumor was densely cellular with marked atypia and frequent binucleation, and lacked pineocytomatous rosettes\u2014features most consistent with a pineal parenchymal tumor of intermediate differentiation in humans. No evidence of metastasis was observed. Pineal tumors are exceptionally rare in domestic animals, with limited documentation in species such as dogs, horses, goats, cattle, and birds. To our knowledge, PPT has not been reported previously in a rabbit, underscoring the diagnostic challenges associated with intracranial neoplasms in this species.\n                  <\/jats:p>","DOI":"10.1177\/10406387251371014","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:16:11Z","timestamp":1758816971000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pineal parenchymal tumor in a domestic rabbit"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7169-8504","authenticated-orcid":false,"given":"Katti R.","family":"Crakes","sequence":"first","affiliation":[{"name":"Departments of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles G.","family":"Eberhart","sequence":"additional","affiliation":[{"name":"Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"John A.","family":"Flanders","sequence":"additional","affiliation":[{"name":"Maryland Zoo in Baltimore (Flanders), Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Trupkiewicz","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12061"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985820973460"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098587801500410"},{"key":"e_1_3_3_5_2","first-page":"396","volume-title":"Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals","author":"Cantile C","unstructured":"Cantile C, Youssef S. Neoplastic diseases of the nervous system. In: Maxie MG, ed. Jubb, Kennedy, and Palmer\u2019s Pathology of Domestic Animals. 6th ed. Vol. 1. Elsevier, 2015:396\u2013406.","edition":"6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198211000-00003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000565"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.28"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2004.04.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588201900516"},{"key":"e_1_3_3_11_2","first-page":"255","article-title":"Ependymoma in a rabbit","volume":"29","author":"Kinkler RJ","year":"1979","unstructured":"Kinkler RJ, Jepsen PL. Ependymoma in a rabbit. 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Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier. 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