{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:07:32Z","timestamp":1784264852503,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Malakoplakia is an uncommon granulomatous disease reported to affect mainly the urinary bladder and, less frequently, the urogenital tract, gastrointestinal tract, and lymph nodes. We describe cases of malakoplakia within the renal medulla of 2 dogs. Both dogs had a history of recurrent urinary tract infections with urine culture growth of\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    . Autopsy findings in dog 1 included ~60 tan-to-yellow, irregular nodules within the renal medulla, and tan-to-red, semi-firm nodules within the urinary bladder mucosa. Dog 2 had no gross changes within the kidneys but rather had ~20 red, semi-firm nodules along the surface of the apex of the urinary bladder. Histologically, the renal medulla of both dogs had sheets of foamy IBA1-positive macrophages with cytoplasmic granules and inclusions of intensely periodic acid\u2013Schiff (PAS)-positive and occasional intracytoplasmic von Kossa\u2013 and Prussian blue\u2013positive Michaelis\u2013Gutmann bodies, consistent with malakoplakia. Fluorescence in situ hybridization and\/or immunohistochemistry confirmed\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    within macrophages. An underlying endocrinopathy could be a predisposing factor in the development of malakoplakia in older dogs.\n                  <\/jats:p>","DOI":"10.1177\/10406387251395699","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:15:55Z","timestamp":1764224155000},"page":"342-345","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Escherichia coli<\/i>\n                    \u2013associated renal malakoplakia in 2 dogs"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1630-1807","authenticated-orcid":false,"given":"Haley E.","family":"Dodson","sequence":"first","affiliation":[{"name":"Departments of Veterinary Pathobiology, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-281X","authenticated-orcid":false,"given":"Paula R.","family":"Giaretta","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellyn E.","family":"McNulty","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Aicher","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenessa A.","family":"Winston","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"Niche Diagnostics, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3768-0743","authenticated-orcid":false,"given":"Raquel R.","family":"Rech","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathobiology, College of Veterinary Medicine &amp; Biomedical Sciences, Texas A&amp;M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2008.02.002"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6794"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.20.12.0676"},{"key":"e_1_3_3_5_2","article-title":"Successful treatment of vaginal malakoplakia in a young cat","volume":"2","author":"Cattin RP","year":"2016","unstructured":"Cattin RP, et al. 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