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Neurologic examination indicated a forebrain lesion, and MRI revealed a large, contrast-enhancing mass centered at the right cribriform plate, extending into the cranial vault and causing brain compression. CSF analysis showed neutrophilic pleocytosis with neoplastic epithelial cells. Because of further clinical deterioration, the patient was euthanized. Postmortem examination revealed a large nasal mass extending into the brain and right orbit, with infiltration into the right olfactory lobe. Histologically, the mass was identified as an undifferentiated carcinoma with metastases along the leptomeninges as far caudal as the L3-L4 segment of the spinal cord. Nasal origin was supported by strong pan-cytokeratin and E-cadherin positivity and negative staining to synaptophysin, neural-specific enolase, S100, and CD18; partial positivity to vimentin suggested epithelial-to-mesenchymal transition in portions of the neoplasm. These findings confirmed leptomeningeal carcinomatosis secondary to the primary nasal carcinoma.<\/jats:p>","DOI":"10.1177\/10406387251410488","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:37:06Z","timestamp":1775709426000},"page":"1009-1013","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nasal carcinoma with leptomeningeal carcinomatosis in a dog"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8701-9962","authenticated-orcid":false,"given":"Maxwell","family":"Beecroft","sequence":"first","affiliation":[{"name":"Departments of Population Health and Pathobiology College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9837-7188","authenticated-orcid":false,"given":"Gilad","family":"Fefer","sequence":"additional","affiliation":[{"name":"Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"Patterson","sequence":"additional","affiliation":[{"name":"Departments of Population Health and Pathobiology College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-2167","authenticated-orcid":false,"given":"Brigid","family":"Troan","sequence":"additional","affiliation":[{"name":"Departments of Population Health and Pathobiology College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-9791","authenticated-orcid":false,"given":"Raisa","family":"Velez-Contreras","sequence":"additional","affiliation":[{"name":"Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-7338"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<660::AID-CNCR2820420237>3.0.CO;2-E"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90254-0"},{"key":"e_1_3_3_5_2","article-title":"Ovarian adenocarcinoma with leptomeningeal metastases","volume":"14","author":"Bayas A","year":"2022","unstructured":"Bayas A, et al Ovarian adenocarcinoma with leptomeningeal metastases. 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