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Upon presentation, the patient was bright and alert, with a corticosteroid stress leukogram, hyperglycemia, and mildly increased blood urea nitrogen and creatine kinase activity. A firm, 15 \u00d7 10-cm, non-painful left-sided proximal cervical mass and ruminal tympany were appreciable. A fine-needle aspirate of the mass was performed, and cytological findings were consistent with a neuroendocrine neoplasm. Given the large size of the mass and poor prognosis, the owner elected euthanasia. At autopsy, a firm 15 \u00d7 12 \u00d7 8-cm mass effaced the left lobe of the thyroid gland. Histological examination confirmed a thyroid follicular-compact carcinoma with metastasis to the deep cervical lymph nodes. Neoplastic cells showed immunolabeling for thyroglobulin, 10% of the neoplastic cells exhibited immunolabeling for thyroid transcription factor 1 (TTF1), and none of the neoplastic cells showed immunolabeling for synaptophysin. Although the cytological features were typical of neuroendocrine neoplasia, immunohistochemistry excluded a thyroid medullary neoplasm. Unlike C-cell and ultimobranchial neoplasms, thyroid follicular carcinomas are rarely reported in cattle. The thyroid follicular-compact carcinoma described herein was associated with acute tympany.<\/jats:p>","DOI":"10.1177\/10406387251411283","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:40:57Z","timestamp":1769755257000},"page":"545-549","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tympany in a cow secondary to a follicular-compact thyroid carcinoma with metastases"],"prefix":"10.1177","volume":"38","author":[{"given":"Emily","family":"Zuber","sequence":"first","affiliation":[{"name":"Texas A&amp;M Veterinary Diagnostic Laboratory, College Station, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Bastos Lopes","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Mid-Atlantic Veterinary Pathology LLC, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Bayne","sequence":"additional","affiliation":[{"name":"linical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Cole","sequence":"additional","affiliation":[{"name":"linical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor J.","family":"Towns","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-3774","authenticated-orcid":false,"given":"Daniel Felipe","family":"Barrantes Murillo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02062.x"},{"key":"e_1_3_3_3_2","first-page":"195","article-title":"A survey on neoplasia in domestic species over a 40-year period from 1935 to 1974 in the Republic of South Africa. 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