{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:13Z","timestamp":1787019013341,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    We describe a 3-y-old Standard Poodle that was fed a raw elk-meat diet and developed anorexia, icterus, and markedly elevated liver enzyme activities. Histopathology of the pancreatic and liver biopsy specimens revealed lymphohistiocytic pancreatitis and hepatitis with intraepithelial protozoa. Histologically,\n                    <jats:italic toggle=\"yes\">Hammondia<\/jats:italic>\n                    spp. are indistinguishable from\n                    <jats:italic toggle=\"yes\">Neospora caninum.<\/jats:italic>\n                    Therefore, we employed PCR and amplicon sequencing to further investigate our case. Amplification and sequencing of the ITS1 marker matched 100% with\n                    <jats:italic toggle=\"yes\">Hammondia heydorni<\/jats:italic>\n                    . Intrapancreatic involvement and the histopathologic features of hepatic and pancreatic\n                    <jats:italic toggle=\"yes\">H. heydorni<\/jats:italic>\n                    infection have not been reported previously in dogs, to our knowledge.\n                    <jats:italic toggle=\"yes\">H. heydorni<\/jats:italic>\n                    is a coccidian organism with an obligatory 2-host life cycle. The definitive hosts are dogs and coyotes; the intermediate hosts are mostly ruminants, including cervids. Ingesting tissue cysts within the skeletal muscle of the intermediate hosts leads to infection in the definitive hosts.\n                    <jats:italic toggle=\"yes\">H. heydorni<\/jats:italic>\n                    has been considered clinically inconsequential; however, increasing reports note gastrointestinal and hepatic disease in dogs associated with this organism, and\n                    <jats:italic toggle=\"yes\">H. heydorni<\/jats:italic>\n                    is considered an emerging pathogen in dogs. Infection in our case was associated with ingestion of raw cervid meat; cases of\n                    <jats:italic toggle=\"yes\">H. heydorni<\/jats:italic>\n                    infection are invariably linked to ingestion of raw-meat diets.\n                  <\/jats:p>","DOI":"10.1177\/10406387261419432","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:12:31Z","timestamp":1770977551000},"page":"473-478","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatic and biliary duct\n                    <i>Hammondia heydorni<\/i>\n                    infection in a dog fed a raw elk-meat diet"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3706-9648","authenticated-orcid":false,"given":"Darian","family":"Giannino","sequence":"first","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine","family":"Peters-Kennedy","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manigandan","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Shearer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VCA CARE Centre, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6036-9895","authenticated-orcid":false,"given":"Mason","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16565"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.33899\/ijvs.2019.126052.1219"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_2_5_2","article-title":"The detection and characterisation of Neospora\/Hammondia-like oocysts from naturally infected dogs within the same urban region of Australia","author":"Ash A","year":"2015","unstructured":"Ash A, et al The detection and characterisation of Neospora\/Hammondia-like oocysts from naturally infected dogs within the same urban region of Australia. Vet Parasitol Reg Stud Reports 2015;1\u20132:47\u201350.","journal-title":"Vet Parasitol Reg Stud Reports"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(88)90033-7"},{"key":"e_1_3_2_7_2","unstructured":"Bowman DD. Georgis\u2019 Parasitology for Veterinarians. 11th ed. Elsevier 2021:106."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.12.1474"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Deplazes P et al Parasitology in Veterinary Medicine. Wageningen Academic Publishers 2016:109\u2013110.","DOI":"10.3920\/978-90-8686-274-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-324R"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000055098"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2006.00155.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14866"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12330"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2013.04.035"},{"key":"e_1_3_2_16_2","first-page":"1304","volume-title":"Greene\u2019s Infectious Diseases of the Dog and Cat","author":"Lappin MR","year":"2023","unstructured":"Lappin MR, Dubey JP. Cystoisosporiasis and other enteric coccidioses. In: Sykes JE, et al, eds. Greene\u2019s Infectious Diseases of the Dog and Cat. 5th ed. Elsevier, 2023:1304.","edition":"5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2017.07.024"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.10-0448"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1590\/0103-8478cr20151365"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.08.008"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-93R"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-0890-2350"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1988.9694179"},{"key":"e_1_3_2_24_2","first-page":"61","article-title":"Morphological classification of biliary disorders of the canine and feline liver. In: Rothuizen J, et al. eds. WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases","author":"van den Ingh TSGAM","year":"2006","unstructured":"van den Ingh TSGAM, et al Morphological classification of biliary disorders of the canine and feline liver. In: Rothuizen J, et al. eds. WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Diseases. Society of Comparative Hepatology, 2006:61\u201376.","journal-title":"Society of Comparative Hepatology"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387261419432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387261419432","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387261419432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:29:52Z","timestamp":1777681792000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387261419432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/10406387261419432"],"URL":"https:\/\/doi.org\/10.1177\/10406387261419432","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]}}}