{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:20:57Z","timestamp":1789395657050,"version":"build-2803163510"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Antech Diagnostics, Inc"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Canine pheochromocytomas remain difficult to diagnose, and reports of RIs for urinary metanephrines (metanephrine and normetanephrine) are scarce. Prior urinary metanephrines:creatinine (uMNs:Cr) ratio RIs are reported with free metanephrines and apply only to voided urine samples. We recruited 40 subclinical client-owned and staff-owned dogs from a veterinary hospital. Among those, 38 dogs were considered healthy based on normal bloodwork and adrenal glands of normal size on ultrasonographic examination. uMNs:Cr ratios were measured using liquid chromatography\u2013tandem mass spectrometry (LC-MS\/MS) on urine samples collected by ultrasound-guided cystocentesis. We found no statistical difference between acidified and non-acidified urine samples. The RIs were 17\u2013117 for the total metanephrine:Cr ratio and 37\u2013223\u2009nmol\/mmol for the normetanephrine:Cr ratio. We confirmed that acidification of urine is not necessary. uMNs:Cr ratios can be measured in urine collected by cystocentesis. Metanephrines measurements should be included when investigating a suspicion of pheochromocytoma in dogs and can be requested easily by veterinarians in general practice.<\/jats:p>","DOI":"10.1177\/10406387261433471","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:01:07Z","timestamp":1774951267000},"page":"972-979","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reference intervals of urinary metanephrines: creatinine ratios in dogs: comparison of acidified and non-acidified samples collected by cystocentesis"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3558-7010","authenticated-orcid":false,"given":"Sol\u00e8ne","family":"Niederlender","sequence":"first","affiliation":[{"name":"Internal Medicine, CHV Hopia Univet, Guyancourt, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Museux","sequence":"additional","affiliation":[{"name":"Medical Consulting Team, Antech Diagnostics, Inc., Mars Petcare Science &amp; Diagnostics, Massy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8870-3391","authenticated-orcid":false,"given":"Maureen","family":"Lazard","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, CHV AniCura Pommery, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzy Y. 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