{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:04:17Z","timestamp":1789398257707,"version":"build-2803163510"},"reference-count":65,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001343","name":"university of pretoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001343","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health and Welfare Sector Education and Training Authority"},{"DOI":"10.13039\/501100008422","name":"university of pretoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008422","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Canine parvovirus is one of the most common causes of infectious enteritis in puppies worldwide. Although various biomarkers have been evaluated to predict prognosis in dogs with parvoviral enteritis (CPE), many are not feasible in routine practice. The neutrophil myeloperoxidase index (MPXI; derived from the Advia 2120 hematology analyzer, Siemens), has shown promise as a marker of inflammation and disease severity in other species. We compared the MPXI in 47 client-owned dogs with established prognostic indicators, including total WBC, neutrophil and lymphocyte count, and serum concentrations of total thyroxine, cortisol, and C-reactive protein (CRP). The MPXI in dogs with CPE did not differ significantly from healthy controls when measured at admission (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.444), at 24\u2009h (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.332), or at 48\u2009h (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.279) after admission. At 24\u2009h after admission, MPXI had a strong positive correlation with serum cortisol (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.87;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and CRP (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u20090.71;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003) concentrations and a strong negative correlation with WBC (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009\u22120.82;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), neutrophil (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009\u22120.77;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and lymphocyte (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009\u22120.90;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) counts, as well as serum thyroxine concentration (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    \u2009=\u2009\u22120.78;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). MPXI did not distinguish between diseased and healthy animals. However, increased MPXI in dogs with parvoviral enteritis may indicate the presence of immunoparalysis and be associated with a worse prognosis. Larger prospective studies, including mortality data, are warranted to evaluate MPXI as an accessible and cost-effective prognostic biomarker in CPE.\n                  <\/jats:p>","DOI":"10.1177\/10406387261436360","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:25:18Z","timestamp":1775305518000},"page":"936-947","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil myeloperoxidase index in juvenile dogs with parvoviral enteritis"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1790-9427","authenticated-orcid":false,"given":"Louis C.","family":"Loubser","sequence":"first","affiliation":[{"name":"Department of Companion Animal Clinical Studies, University of Pretoria, Pretoria, South Africa"},{"name":"Panorama Veterinary Clinic and Specialist Centre, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5774-0320","authenticated-orcid":false,"given":"Willem J.","family":"Botha","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies, University of Pretoria, Pretoria, South Africa"},{"name":"Panorama Veterinary Clinic and Specialist Centre, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9798-1874","authenticated-orcid":false,"given":"Yolandi","family":"Rautenbach","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies, University of Pretoria, Pretoria, South Africa"},{"name":"IDEXX Laboratories, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4284-6074","authenticated-orcid":false,"given":"Anri","family":"Celliers","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Studies, University of Pretoria, Pretoria, South Africa"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12810"},{"key":"e_1_3_3_3_2","first-page":"652","article-title":"Analytical performance of a highly sensitive C-reactive protein-based immunoassay and the effects of laboratory variables on levels of protein in blood","volume":"10","author":"Aziz N","year":"2003","unstructured":"Aziz N, et al. 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Serial measurement of myeloperoxidase index and its association with outcome in hospitalized dogs with parvoviral enteritis: preliminary results. Poster 57. 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