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Bovine ependymomas have been reported only sporadically, with limited morphologic descriptions and, to our knowledge, without immunohistochemical characterization. Here, we describe the gross, histologic, and immunophenotypic features of a papillary ependymoma in the brain of a 7.5-y-old cow that was a bovine spongiform encephalopathy suspect. Grossly, a large, intraparenchymal, well-demarcated mass occupied the left cerebral hemisphere, extending from the frontal to the occipital lobe and communicating with the left lateral ventricle. Histologically, the neoplasm was composed of elongated-to-columnar cells arranged predominantly in perivascular pseudorosettes with prominent papillary architecture. Immunohistochemically, &gt;95% of neoplastic cells had strong cytoplasmic glial fibrillary acidic protein immunolabeling, which was accentuated in perivascular processes; ~20% of neoplastic cells were also immunolabeled for vimentin. Neoplastic cells lacked immunolabeling for pan-cytokeratin, S100, oligodendrocyte transcription factor 2, NeuN, synaptophysin, and E-cadherin. The combined morphologic and immunophenotypic findings supported a diagnosis of papillary ependymoma and excluded morphologic mimics.<\/jats:p>","DOI":"10.1177\/10406387261444330","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:15:15Z","timestamp":1778825715000},"page":"1375-1379","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intracerebral papillary ependymoma in a cow"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3534-4219","authenticated-orcid":false,"given":"Stefano","family":"Bagatella","sequence":"first","affiliation":[{"name":"Division of Neurological Sciences, University of Bern, Bern, Switzerland"},{"name":"Department of Veterinary Sciences, University of Turin, Grugliasco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronja","family":"Kauer","sequence":"additional","affiliation":[{"name":"Division of Neurological Sciences, University of Bern, Bern, Switzerland"},{"name":"Tierarztpraxis Ostalb, Aalen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3749-4238","authenticated-orcid":false,"given":"Margherita","family":"Polidori","sequence":"additional","affiliation":[{"name":"Division of Neurological Sciences, University of Bern, Bern, Switzerland"},{"name":"Vetsuisse Faculty, and Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3569-8547","authenticated-orcid":false,"given":"Anna","family":"Oevermann","sequence":"additional","affiliation":[{"name":"Division of Neurological Sciences, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2002.100107.x"},{"key":"e_1_3_3_3_2","first-page":"195","article-title":"A survey on neoplasia in domestic species over a 40-year period from 1935 to 1974 in the Republic of South Africa. 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