{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:20:57Z","timestamp":1789395657222,"version":"build-2803163510"},"reference-count":13,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Canine chronic enteropathy (CCE) includes persistent gastrointestinal disorders that may be associated with antimicrobial-resistant bacteria. We evaluated the correlation between clinical severity of CCE and the presence of extended-spectrum beta-lactamase (ESBL)-producing\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    in dogs with CCE. We assessed 64 dogs using the canine chronic enteropathy clinical activity index (CCECAI) and analyzed rectal swabs for\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    and ESBL detection.\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    was isolated from 28 dogs (44%), with ESBL-positive strains identified in 8 (12%). All ESBL-positive cases had severe clinical scores (CCECAI\u2009\u2265\u20099), with a strong association between ESBL phenotype and disease severity (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These multidrug-resistant isolates remained susceptible to imipenem. Histologic findings confirmed marked intestinal inflammation in ESBL-positive cases. No age or sex association was observed. Our results emphasize the clinical relevance of ESBL-producing\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    in severe CCE and support the inclusion of microbial profiling in diagnostic and therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1177\/10406387261447252","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:19:52Z","timestamp":1778825992000},"page":"1028-1032","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the association of ESBL-producing\n                    <i>Escherichia coli<\/i>\n                    with clinical severity of chronic enteropathy in dogs in Brazil"],"prefix":"10.1177","volume":"38","author":[{"given":"Giovanna","family":"Casagrande","sequence":"first","affiliation":[{"name":"Graduate Program in Animal Health, University of Caxias do Sul, Caxias do Sul, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7770-3483","authenticated-orcid":false,"given":"Rafael Sartori","family":"Flores","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Health, University of Caxias do Sul, Caxias do Sul, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Bossardi","sequence":"additional","affiliation":[{"name":"MellisLab, Caxias do Sul, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Felipe","family":"Streck","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Health, University of Caxias do Sul, Caxias do Sul, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anelise Bonilla","family":"Trindade-Gerardi","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-0777","authenticated-orcid":false,"given":"Helo\u00edsa","family":"Theodoro","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Health, University of Caxias do Sul, Caxias do Sul, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03011.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147321"},{"key":"e_1_3_3_4_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals. 6th ed. CLSI 2023. CLSI supplement VET01S."},{"key":"e_1_3_3_5_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Disk Susceptibility Tests. 13th ed. CLSI 2018\/2020. CLSI document M02."},{"key":"e_1_3_3_6_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. 34th ed. CLSI 2024. CLSI supplement M100."},{"key":"e_1_3_3_7_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing of Bacteria Isolated from Animals. 4th ed. CLSI 2018. CLSI supplement VET08."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12588"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh332"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.923013"},{"key":"e_1_3_3_11_2","unstructured":"Koneman EW et al. Color Atlas and Textbook of Diagnostic Microbiology. 5th ed. Lippincott Williams & Wilkins 2001."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70041-0"},{"key":"e_1_3_3_13_2","first-page":"3305","article-title":"Routine antibiotic therapy in dogs increases the detection of antimicrobial-resistant faecal Escherichia coli","volume":"73","author":"Schmidt VM","year":"2018","unstructured":"Schmidt VM, et al. Routine antibiotic therapy in dogs increases the detection of antimicrobial-resistant faecal Escherichia coli. J Antimicrob Chemother 2018;73:3305\u20133316.","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051907"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387261447252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387261447252","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387261447252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:47:57Z","timestamp":1789393677000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387261447252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/10406387261447252"],"URL":"https:\/\/doi.org\/10.1177\/10406387261447252","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]}}}