{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:44:48Z","timestamp":1791801888284,"version":"4.3.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>\n                    Upper digestive tract neoplasms associated with ingestion of\n                    <jats:italic toggle=\"yes\">Pteridium<\/jats:italic>\n                    spp. (bracken fern) have been documented in cattle but not in buffalo. Here, we describe upper digestive tract lesions associated with the ingestion of\n                    <jats:italic toggle=\"yes\">P. esculentum<\/jats:italic>\n                    subsp.\n                    <jats:italic toggle=\"yes\">arachnoideum<\/jats:italic>\n                    in 3 water buffalo (\n                    <jats:italic toggle=\"yes\">Bubalus bubalis<\/jats:italic>\n                    ) in Brazil. Gross inspection revealed proliferative and ulcerative lesions in the mucosa of the base of the tongue, oropharynx, and esophagus in all 3 cases. Proliferative lesions were well-demarcated, white-to-brown, exophytic nodules on the lingual and oropharyngeal mucosa (papillomas, cases 1\u20133); a well-demarcated, white nodular fibroma in the distal esophageal submucosa (case 1); and locally infiltrative areas of mucosal thickening with ulceration and dark red-to-brown areas of hemorrhage in the base of the tongue and oropharynx (squamous cell carcinomas [SCCs], cases 1\u20133). Histologically, non-neoplastic lesions were irregular (cases 2, 3) or pseudocarcinomatous (case 1) mucosal hyperplasia with parakeratosis (cases 1\u20133) and dysplasia (cases 1, 2) in the base of the tongue, oropharynx, and esophagus. Neoplastic lesions were papillomas affecting the base of the tongue, oropharynx, and esophagus (cases 1\u20133); a submucosal distal esophageal fibroma (case 1); and SCCs affecting the base of the tongue and oropharynx (cases 1\u20133). Mucosal ulceration was associated with the SCCs in all cases. Inflammation was lymphoplasmacytic. Esophageal vascular myxomatous degeneration or proliferation with fibrosis were present. The diagnoses of\n                    <jats:italic toggle=\"yes\">Pteridium<\/jats:italic>\n                    -associated disease were based on the epidemiologic and pathologic findings, which were identical to those observed in cattle.\n                  <\/jats:p>","DOI":"10.1177\/10406387261452989","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:58:03Z","timestamp":1781600283000},"page":"1296-1302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoplastic and non-neoplastic lesions in the upper digestive tract associated with the ingestion of\n                    <i>Pteridium esculentum<\/i>\n                    subsp.\n                    <i>arachnoideum<\/i>\n                    by 3 water buffalo in Brazil"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2782-8639","authenticated-orcid":false,"given":"Paulo V.","family":"Peixoto","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Veterin\u00e1ria, Patologia e Ci\u00eancias Cl\u00ednicas, Instituto de Veterin\u00e1ria, Universidade Federal Rural do Rio de Janeiro, Serop\u00e9dica, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5899-3469","authenticated-orcid":false,"given":"Juliana F.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Veterin\u00e1ria, Patologia e Ci\u00eancias Cl\u00ednicas, Instituto de Veterin\u00e1ria, Universidade Federal Rural do Rio de Janeiro, Serop\u00e9dica, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-319X","authenticated-orcid":false,"given":"Bartolomeu B. N.","family":"Santos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Veterin\u00e1ria, Patologia e Ci\u00eancias Cl\u00ednicas, Instituto de Veterin\u00e1ria, Universidade Federal Rural do Rio de Janeiro, Serop\u00e9dica, Brazil"},{"name":"Setor de Patologia Veterin\u00e1ria, Universidade Federal de Vi\u00e7osa, Vi\u00e7osa, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-0837","authenticated-orcid":false,"given":"Alexandre","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Barra Mansa, Barra Mansa, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C.","family":"Oleg\u00e1rio","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Virologia, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio S. L.","family":"Barros","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Porto Alegre and Laborat\u00f3rio de Anatomia Patol\u00f3gica, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-2836","authenticated-orcid":false,"given":"Daniel R.","family":"Rissi","sequence":"additional","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory, Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-2697","authenticated-orcid":false,"given":"Ticiana N.","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Veterin\u00e1ria, Patologia e Ci\u00eancias Cl\u00ednicas, Instituto de Veterin\u00e1ria, Universidade Federal Rural do Rio de Janeiro, Serop\u00e9dica, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03856.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2006.01.001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep36480"},{"key":"e_1_3_2_5_2","first-page":"489","article-title":"Occurrence of enzootic hematuria and epidermoid carcinomas in the upper digestive tract in cattle in Brazil","volume":"2","author":"D\u00f6bereiner J","year":"1967","unstructured":"D\u00f6bereiner J, et al. Occurrence of enzootic hematuria and epidermoid carcinomas in the upper digestive tract in cattle in Brazil. Pesqui Vet Bras 1967;2:489\u2013504.","journal-title":"Pesqui Vet Bras"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204656"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-9-2437"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/274215a0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12127"},{"key":"e_1_3_2_10_2","first-page":"156","article-title":"Pteridium aquilinum (bracken fern) toxicity in cattle in the humid Chaco of Tarija, Bolivia","volume":"43","author":"Marrero E","year":"2001","unstructured":"Marrero E, et al. Pteridium aquilinum (bracken fern) toxicity in cattle in the humid Chaco of Tarija, Bolivia. Vet Hum Toxicol 2001;43:156\u2013158.","journal-title":"Vet Hum Toxicol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2010.04.009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119181200.ch13"},{"key":"e_1_3_2_13_2","unstructured":"Ogliari D. [Experimental reproduction of squamous cell carcinoma in the upper alimentary tract of cattle through ingestion of Pteridium esculentum subsp. arachnoideum and possible association with papillomavirus]. PhD thesis. Universidade do Estado de Santa Catarina 2022. Portuguese. https:\/\/www.udesc.br\/arquivos\/cav\/id_cpmenu\/3159\/Tese_Daiane_Ogliari_16760428488246_3159.pdf"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2004000100007"},{"key":"e_1_3_2_15_2","first-page":"779","article-title":"A urinary bladder tumor induced by a bovine cutaneous papilloma agent","volume":"19","author":"Olson C","year":"1959","unstructured":"Olson C, et al. A urinary bladder tumor induced by a bovine cutaneous papilloma agent. Cancer Res 1959;19:779\u2013782.","journal-title":"Cancer Res"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1957.tb00464.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-6875"},{"key":"e_1_3_2_18_2","unstructured":"Sambrook J et al. Molecular Cloning: A Laboratory Manual. Vol. 3. Cold Spring Harbor 2001."},{"key":"e_1_3_2_19_2","first-page":"349","volume-title":"Plantas t\u00f3xicas do Brasil: para animais de produ\u00e7\u00e3o","author":"Tokarnia CH","year":"2012","unstructured":"Tokarnia CH, et al. Plantas de a\u00e7\u00e3o radiomim\u00e9tica [Plants with radiomimetic action]. In: Tokarnia CH, et al., eds. Plantas t\u00f3xicas do Brasil: para animais de produ\u00e7\u00e3o [Toxic plants of Brazil: for production animals]. 2nd ed. Editora Helianthus, 2012:349\u2013364. Portuguese.","edition":"2"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387261452989","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10406387261452989","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10406387261452989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T09:47:18Z","timestamp":1791798438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10406387261452989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/10406387261452989"],"URL":"https:\/\/doi.org\/10.1177\/10406387261452989","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}