{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:44:50Z","timestamp":1791801890137,"version":"4.3.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>\n                    In a herd of 70 crossbred beef calves (10\u201312-mo-old) managed extensively in Santa Catarina, Brazil, 14 animals developed clinical signs; 9 of the 14 died within 7\u2009d of accidental ingestion of a copper sulfate (CuSO\n                    <jats:sub>4<\/jats:sub>\n                    ) product. Affected calves were lethargic, anorectic, and had green diarrhea. A bag containing remnants of blue-green product was found near the carcasses; this product was later determined to contain 53% metallic copper (Cu; dry weight). Postmortem examinations were performed on 3 calves found dead; tissue samples were collected for histopathology and mineral analysis. Gross findings included yellow-orange livers, distended gallbladders, green-blue intestinal contents, and hyperemic abomasal mucosae. Histologically, hepatic and renal necrosis varied in severity, with moderate Cu accumulation in both organs on rhodanine staining. Renal lesions were more prominent than hepatic lesions. Cu concentrations were 483\u2009mg\/kg in liver and 838\u2009mg\/kg in kidney; both were above RIs. Blood samples from 5 surviving calves were submitted for hematologic and biochemical testing; liver enzyme activities were elevated in most animals. We highlight the diagnostic value of kidney histopathology and toxicology in cases of acute copper toxicosis resulting from short-term, massive ingestion. To our knowledge, spontaneous acute CuSO\n                    <jats:sub>4<\/jats:sub>\n                    toxicosis has not been reported previously in cattle in Brazil.\n                  <\/jats:p>","DOI":"10.1177\/10406387261457395","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:20:28Z","timestamp":1784092828000},"page":"1246-1250","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute copper sulfate poisoning in yearling beef cattle in Brazil"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-8563","authenticated-orcid":false,"given":"Thaiza","family":"Savaris","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, Ross University, Basseterre, St. Kitts and Nevis, West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiane","family":"Ogliari","sequence":"additional","affiliation":[{"name":"Animal Pathology Laboratory, Agroveterinary Sciences Center, University of Santa Catarina State, Lages, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tainara R.","family":"Tineli","sequence":"additional","affiliation":[{"name":"Animal Pathology Laboratory, Agroveterinary Sciences Center, University of Santa Catarina State, Lages, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio S\u00e9rgio","family":"Varela J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Histolog, Institute of Biological Sciences, Federal University of Rio Grande, Rio Grande, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Gava","sequence":"additional","affiliation":[{"name":"Animal Pathology Laboratory, Agroveterinary Sciences Center, University of Santa Catarina State, Lages, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-84782013001000021"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.100267"},{"key":"e_1_3_3_4_2","first-page":"307","article-title":"The toxicology and composition of bovine tissues after parenteral administration of high levels of copper salts","volume":"29","author":"Bohman VR","year":"1987","unstructured":"Bohman VR, et al. The toxicology and composition of bovine tissues after parenteral administration of high levels of copper salts. Vet Hum Toxicol 1987;29:307\u2013312.","journal-title":"Vet Hum Toxicol"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1986.188.04.406"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214584"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-5318-4.00008-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2012000100001"},{"key":"e_1_3_3_9_2","first-page":"547","volume-title":"Toxicologia aplicada \u00e0 medicina veterin\u00e1ria","author":"Ferreira MB","year":"2008","unstructured":"Ferreira MB, Antonelli AC. Intoxica\u00e7\u00e3o por cobre, sel\u00eanio, zinco e cloreto de s\u00f3dio [Copper, selenium, zinc, and sodium chloride poisoning]. In: Spinosa HS, et al., eds. Toxicologia aplicada \u00e0 medicina veterin\u00e1ria [Toxicology Applied to Veterinary Medicine]. Manole, 2008:547\u2013558. Portuguese."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/104063879100300316"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2020.901.252"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/2046-0481-67-20"},{"key":"e_1_3_3_13_2","first-page":"289","article-title":"Investigation of copper poisoning in adult cows by the Veterinary Laboratories Agency","volume":"10","author":"Livesey CT","year":"2002","unstructured":"Livesey CT, et al. Investigation of copper poisoning in adult cows by the Veterinary Laboratories Agency. Cattle Pract 2002;10:289\u2013294.","journal-title":"Cattle Pract"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-6526"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1974.tb06885.x"},{"key":"e_1_3_3_16_2","first-page":"315","article-title":"Acute sheep poisoning from a copper sulfate footbath","volume":"46","author":"Ortolani EL","year":"2004","unstructured":"Ortolani EL, et al. Acute sheep poisoning from a copper sulfate footbath. Vet Hum Toxicol 2004;46:315\u2013318.","journal-title":"Vet Hum Toxicol"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.70062"},{"key":"e_1_3_3_18_2","unstructured":"Sindira\u00e7\u00f5es (Brazilian Association of Animal Feed Industries) et al. Brazilian Compendium of Animal Nutrition. 4th ed. 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