{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:44:58Z","timestamp":1791801898508,"version":"4.3.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Mycobacterium avium<\/jats:italic>\n                    subsp.\n                    <jats:italic toggle=\"yes\">hominissuis<\/jats:italic>\n                    (MAH) causes pulmonary and disseminated infections in immunocompromised humans. In pigs, MAH commonly causes subclinical infections that lead to granulomatous lesions in the mesenteric lymph nodes, liver, spleen, and jejunum. MAH infections have been reported less commonly in other animal species and in birds. Here, we report a case of systemic mycobacteriosis caused by MAH in a sheep. The affected animal had a history of hypoproteinemia, weight loss, and fever. Gross pathology findings included serous fluid accumulation in the peritoneal and pleural cavities, patchy dull granular light-red mucosa of the small intestine, diffuse orange-brown discoloration of the liver, and noncollapsing lungs that were mottled pink to dark-red. Histologically, granulomas were present in the intestines, mesenteric lymph nodes, liver, spleen, kidneys, lungs, and brain. MAH was isolated from the liver, spleen, and feces. Whole-genome sequencing revealed a mobile genetic element\u2014an ISMAP\n                    <jats:italic toggle=\"yes\">02<\/jats:italic>\n                    -like sequence\u2014in the MAH genome. An ISMAP\n                    <jats:italic toggle=\"yes\">02<\/jats:italic>\n                    -like sequence in mycobacteria other than\n                    <jats:italic toggle=\"yes\">Mycobacterium avium<\/jats:italic>\n                    subsp.\n                    <jats:italic toggle=\"yes\">paratuberculosis<\/jats:italic>\n                    (MAP) may interfere with the detection of MAP by PCR assays targeting ISMAP\n                    <jats:italic toggle=\"yes\">02<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1177\/10406387261464590","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:21:31Z","timestamp":1783754491000},"page":"1380-1385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic mycobacteriosis caused by\n                    <i>Mycobacterium avium<\/i>\n                    subspecies\n                    <i>hominissuis<\/i>\n                    in a sheep"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4790-0319","authenticated-orcid":false,"given":"Nagaraja","family":"Thirumalapura","sequence":"first","affiliation":[{"name":"Wisconsin Veterinary Diagnostic Laboratory, University of Wisconsin\u2013Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj K.","family":"Sekhwal","sequence":"additional","affiliation":[{"name":"Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Camp","sequence":"additional","affiliation":[{"name":"National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, United States Department of Agriculture, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Farrell","sequence":"additional","affiliation":[{"name":"National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, United States Department of Agriculture, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Bravo","sequence":"additional","affiliation":[{"name":"National Veterinary Services Laboratories, Animal and Plant Health Inspection Service, United States Department of Agriculture, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Livengood","sequence":"additional","affiliation":[{"name":"Pennsylvania 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