{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:30:49Z","timestamp":1788201049857,"version":"build-2803163510"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"abstract":"<jats:p>Canine extramedullary plasma cell tumors (cePCTs) are common integumentary round-cell tumors. The presence of adipocytes among round cells, which is thought to be the result of trapping of subcutaneous adipocytes, is reported as a helpful diagnostic feature to distinguish cePCTs from other round-cell tumors in the skin. Here, we report our retrospective analysis of the prevalence, extent, and distribution of adipocytes in cePCTs from a single institution. We found adipocytes in 73 of 265 (27.5%) cePCT cases diagnosed from 2020\u20132024, suggesting that intra-tumoral adipocytes are a frequent histologic feature in cutaneous cePCTs. We found that 1\u201396% of the mass was composed of adipocytes, as quantified on whole-slide images. Of the cePCTs with adipocytes, 27 (37%) cases did not have significant involvement of the subcutis. Adipocyte-containing cePCTs were more frequent in our case series than were amyloid-producing cePCTs (19; 7%). A subset of 9 cases had limited involvement of the subcutis. The proportion of intra-tumoral adipocytes was far greater (&gt;10%) than would be expected for simple entrapment of subcutaneous adipocytes, suggesting the promotion of proliferation of mature adipocytes by neoplastic cells.<\/jats:p>","DOI":"10.1177\/10406387261478066","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T03:23:26Z","timestamp":1788060206000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intra-tumoral adipocytes in canine extramedullary plasma cell tumors"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-2713","authenticated-orcid":false,"given":"Agust\u00edn","family":"Rebollada-Merino","sequence":"first","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8328-1031","authenticated-orcid":false,"given":"Latasha","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"688","volume-title":"Tumors in Domestic Animals","author":"Agnew DW","year":"2017","unstructured":"Agnew DW, MacLachlan NJ. Tumors of the genital system. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Wiley-Blackwell, 2017:688\u2013722.","edition":"5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.2002.00456.x"},{"key":"e_1_3_3_4_2","first-page":"602","volume-title":"Tumors in Domestic Animals","author":"Cullen JM","year":"2017","unstructured":"Cullen JM. Tumors of the liver and gallbladder. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Wiley-Blackwell, 2017:602\u2013631.","edition":"5"},{"key":"e_1_3_3_5_2","first-page":"463","article-title":"Evidence that prostaglandins modulate lipogenesis in cultured lymphocytes\u2014a comparison with its effect on macrophages and tumour cells","volume":"33","author":"de Bittencourt J\u00fanior PI","year":"1994","unstructured":"de Bittencourt J\u00fanior PI, et al. Evidence that prostaglandins modulate lipogenesis in cultured lymphocytes\u2014a comparison with its effect on macrophages and tumour cells. 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