{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:52:57Z","timestamp":1791039177319,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"abstract":"<jats:p>\n                    Infection by highly pathogenic avian influenza (HPAI) A(H5N1) virus (family\n                    <jats:italic toggle=\"yes\">Orthomyxoviridae<\/jats:italic>\n                    , taxon species\n                    <jats:italic toggle=\"yes\">Alphainfluenzavirus influenzae<\/jats:italic>\n                    ), clade 2.3.4.4b, genotype B3.13, was first diagnosed in dairy cattle in the United States in March 2024. Here, we present a cluster of bovine abortions in whose placentas HPAI A(H5N1) was detected. Only placentas were submitted in all 5 cases received. Grossly, 3 placentas had multifocal edema; no significant gross abnormalities were observed in the other 2 placentas. Microscopically, one placenta had random areas of mineralization and another placenta had mild neutrophilic placentitis. Reverse-transcription quantitative real-time PCR for influenza A virus and avian influenza A virus subtype H5N1 were positive in all 5 placentas. RNAscope in-situ hybridization for matrix protein gene was positive in one placenta. Routine ancillary tests for bovine abortion diagnostic work-up did not detect any other abortifacient pathogens. We speculate that abortion was caused by the HPAI A(H5N1) virus.\n                  <\/jats:p>","DOI":"10.1177\/10406387261483207","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:32:46Z","timestamp":1790832766000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of highly pathogenic avian influenza A(H5N1) virus, clade 2.3.4.4b, genotype B3.13 in placentas from aborted bovine fetuses"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-8384","authenticated-orcid":false,"given":"Melissa","family":"Mac\u00edas-Rioseco","sequence":"first","affiliation":[{"name":"California Animal Health and Food Safety Laboratory, Tulare, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0330-5013","authenticated-orcid":false,"given":"Sharif S.","family":"Aly","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"},{"name":"Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6178-4801","authenticated-orcid":false,"given":"Javier","family":"Asin","sequence":"additional","affiliation":[{"name":"San Bernardino branches, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Cornish","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory, Tulare, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennine","family":"Ochoa","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory, Tulare, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniece R.","family":"Williams","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8517-9288","authenticated-orcid":false,"given":"Ra\u00fal A.","family":"Resend\u00edz-Pozos","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory, Tulare, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Moeller","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory, Tulare, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Jackson","sequence":"additional","affiliation":[{"name":"Davis branches, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagdy R.","family":"ElAshmawy","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"},{"name":"Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-7229","authenticated-orcid":false,"given":"Beate","family":"Crossley","sequence":"additional","affiliation":[{"name":"Davis branches, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-1878","authenticated-orcid":false,"given":"Francisco A.","family":"Uzal","sequence":"additional","affiliation":[{"name":"San Bernardino branches, School of Veterinary Medicine, University of California\u2013Davis, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00225.x"},{"key":"e_1_3_3_3_2","first-page":"637","article-title":"Detection of antibodies to influenza A virus in cattle in association with respiratory disease and reduced milk yield","volume":"143","author":"Brown IH","year":"1998","unstructured":"Brown IH, et al. Detection of antibodies to influenza A virus in cattle in association with respiratory disease and reduced milk yield. Vet Rec 1998;143:637\u2013638.","journal-title":"Vet Rec"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid3007.240508"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07849-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.8.1066"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2249554"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1040638720984114"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07766-6"},{"key":"e_1_3_3_10_2","article-title":"Pathology of influenza A (H5N1) infection in pinnipeds reveals novel tissue tropism and vertical transmission","author":"Fiorito C","year":"2025","unstructured":"Fiorito C, et al. Pathology of influenza A (H5N1) infection in pinnipeds reveals novel tissue tropism and vertical transmission. bioRxiv 2025. 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