{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:04:48Z","timestamp":1789365888324,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"conselho nacional de desenvolvimento cient\u00edfico e tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"coordena\u00e7\u00e3o de aperfei\u00e7oamento de pessoal de n\u00edvel superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005286","name":"funda\u00e7\u00e3o de amparo \u00e0 pesquisa do estado de mato grosso","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005286","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pr\u00f3 Reitoria de Pesquisa da Universidade Federal de Mato Grosso"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Trema micranthum<\/jats:italic>\n                    (L.) Blume (Jamaican nettletree) is a hepatotoxic tree that is widely distributed throughout the Americas and has been associated with poisoning in several domestic animal species. To our knowledge, spontaneous intoxication in cattle has not been reported previously. Here, we describe 2 spontaneous outbreaks of\n                    <jats:italic toggle=\"yes\">T. micranthum<\/jats:italic>\n                    poisoning in Nelore cows in the state of Mato Grosso, Brazil. Affected cattle developed apathy, ataxia, and recumbency, followed by death within hours. Autopsy revealed jaundice and enlarged livers with a diffuse mottled red-and-white appearance. Histologically, severe centrilobular-to-massive hepatocellular coagulative necrosis was observed. Epidemiologic investigation identified recent access to paddocks containing vigorously sprouting\n                    <jats:italic toggle=\"yes\">T. micranthum<\/jats:italic>\n                    following deforestation or tree fall, with clear evidence of grazing. The combination of pathology findings and field investigation established the diagnosis of acute toxic hepatopathy caused by\n                    <jats:italic toggle=\"yes\">T. micranthum<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1177\/10406387261484902","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:42:25Z","timestamp":1789126945000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute hepatic necrosis associated with\n                    <i>Trema micranthum<\/i>\n                    poisoning in cattle in Brazil"],"prefix":"10.1177","author":[{"given":"Wuglenya D. M.","family":"Silva","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5832-3809","authenticated-orcid":false,"given":"Larissa","family":"Sabino","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loriany M.","family":"Gottardi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, University of Cuiab\u00e1, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenyffer A. O. P.","family":"Rondon","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, University of Cuiab\u00e1, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7912-9648","authenticated-orcid":false,"given":"Marcos de A.","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0203-439X","authenticated-orcid":false,"given":"Marlon","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, University of Cuiab\u00e1, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson M.","family":"Colodel","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricio Andrade","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Argenta","family":"Pescador","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-6103","authenticated-orcid":false,"given":"Fernando H.","family":"Furlan","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Mato Grosso, Cuiab\u00e1, Mato Grosso, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.00035.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2011001100009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-7439"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2010000300001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12741"},{"key":"e_1_3_2_7_2","unstructured":"Lorenzi H ed. \u00c1rvores brasileiras: manual de identifica\u00e7\u00e3o e cultivo de plantas arb\u00f3reas nativas do Brasil [Brazilian Trees: A Manual for the Identification and Cultivation of Native Tree Species of Brazil]. Vol 1. 9th ed. Instituto Plantarum 2025. Portuguese."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-7824-en"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12110707"},{"key":"e_1_3_2_10_2","first-page":"573","volume-title":"Australia\u2019s Poisonous Plants, Fungi and Cyanobacteria: A Guide to Species of Medical and Veterinary Importance","author":"McKenzie R","unstructured":"McKenzie R. Poisonous trees. In: Australia\u2019s Poisonous Plants, Fungi and Cyanobacteria: A Guide to Species of Medical and Veterinary Importance. CSIRO, 2020:573\u2013644."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-7759en"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2013001100009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-5150-pvb-7128"},{"key":"e_1_3_2_14_2","article-title":"Intoxicaciones por Plantas, Micotoxinas y Otras Toxinas en Rumiantes y \u00c9quidos de Sudam\u00e9rica","author":"Riet-Correa F","year":"2024","unstructured":"Riet-Correa F, et al. Intoxicaciones por Plantas, Micotoxinas y Otras Toxinas en Rumiantes y \u00c9quidos de Sudam\u00e9rica [Intoxication by Plants, Mycotoxins and other Toxins in Ruminants and Horses in South America]. Davis-Thompson Foundation, 2024. 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