{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:42:58Z","timestamp":1777930978924,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:p>A 6-year study was conducted in 4 dairy herds in Iowa in which Johne's disease was diagnosed previously. Fecal specimens were collected at 6-month intervals from animals 2 years of age and over for mycobacteriologic examination. Serum samples were obtained at 3-month intervals and tested by enzyme-linked immunosorbent assay (ELISA). The antigen used in the ELISA was a potassium chloride extract of a field strain of Mycobacterium paratuberculosis. The ELISA reactions were observed in 87% of the cows from which M. paratuberculosis was isolated. Dairy producers that participated in the Johne's control program reported reduced economic losses. Increased income was attributed to improved milk production, increased value of vaccinated animals sold as replacements to other dairy herds in which Johne's disease had been diagnosed, and the increased market value of slaughter animals removed from the herd.<\/jats:p>","DOI":"10.1177\/104063878900100305","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:10:00Z","timestamp":1305216600000},"page":"223-226","source":"Crossref","is-referenced-by-count":7,"title":["Control of Johne's Disease in Four Commercial Dairy Herds in Iowa"],"prefix":"10.1177","volume":"1","author":[{"given":"Charles O.","family":"Thoen","sequence":"first","affiliation":[{"name":"Departments of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry A.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Postville Veterinary Clinic, Postville, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,7,1]]},"reference":[{"key":"bibr1-104063878900100305","doi-asserted-by":"publisher","DOI":"10.1136\/vr.121.7.142"},{"key":"bibr2-104063878900100305","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(89)90083-7"},{"key":"bibr3-104063878900100305","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.2460\/ajvr.1986.47.10.2226","volume":"47","author":"Collins DM","year":"1986","journal-title":"Am J Vet Res"},{"key":"bibr4-104063878900100305","volume-title":"Vergleichende Untersuchungen zur diagnose der Paratuberkulose des Rindes Mittels KBR, ELISA, und AGIDT","author":"Eingereicht AK","year":"1988"},{"key":"bibr5-104063878900100305","doi-asserted-by":"publisher","DOI":"10.1136\/vr.98.23.461"},{"key":"bibr6-104063878900100305","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.2460\/ajvr.1983.44.08.1602","volume":"44","author":"Hall MR","year":"1983","journal-title":"Am J Vet Res"},{"key":"bibr7-104063878900100305","author":"Labidi A","year":"1989","journal-title":"Acta Leprol"},{"key":"bibr8-104063878900100305","first-page":"225","volume":"36","author":"Larsen AB","year":"1975","journal-title":"Am J Vet Res"},{"key":"bibr9-104063878900100305","unstructured":"McFadden J, Hull E, Taylor JH: 1988, DNA probes to identify and detect\n                      Mycobacterium paratuberculosis\n                      in clinical and veterinary samples. Proc 2nd Int Colloq Paratuberculosis, pp. 201\u2013205. Sept. 22\u201323, 1988."},{"key":"bibr10-104063878900100305","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2460\/javma.1987.190.06.676","volume":"190","author":"Merkal RS","year":"1987","journal-title":"J Am Vet Med Assn"},{"key":"bibr11-104063878900100305","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500205"},{"key":"bibr12-104063878900100305","first-page":"73","volume":"17","author":"Ringdal G","year":"1965","journal-title":"Nord Vet Med"},{"key":"bibr13-104063878900100305","volume-title":"Immunology","author":"Roitt I","year":"1985"},{"key":"bibr14-104063878900100305","volume-title":"Diagnostic procedures in veterinary bacteriology and mycology","author":"Thoen CO","year":"1989","edition":"5"},{"key":"bibr15-104063878900100305","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.2460\/javma.1988.192.11.1609","volume":"192","author":"Thoen CO","year":"1988","journal-title":"J Am Vet Med Assn"},{"key":"bibr16-104063878900100305","first-page":"141","volume":"1","author":"Thoen CO","year":"1983","journal-title":"Vet Lab Diagn"},{"key":"bibr17-104063878900100305","first-page":"838","volume":"174","author":"Thoen CO","year":"1979","journal-title":"J Am Vet Med Assn"},{"key":"bibr18-104063878900100305","unstructured":"Thoen CO, Stumpff CD, Tupper D, 1983, Some observations on naturally occurring paratuberculosis (Johne's disease) in cattle herds in Nebraska, Colorado, and Minnesota. Proc 1st Int Colloq Res Paratuberculosis. Pp. 127\u2013135."},{"key":"bibr19-104063878900100305","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.25.8.1511-1515.1987"},{"key":"bibr20-104063878900100305","unstructured":"Yokomizo Y: 1988, Evaluation of ELISA for the diagnosis of bovine paratuberculosis. A proposal of replacing the complement fixation test with ELISA as the official diagnostic test for paratuberculosis in Japan. Proc 2nd Int Colloq Paratuberculosis, pp. 206\u2013214. 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