{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:29:50Z","timestamp":1790731790747,"version":"4.1.0"},"reference-count":6,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:p>Mass spectrometry\/mass spectrometry (MS\/MS) with collision-activated dissociation (CAD) was utilized to unequivocally distinguish 1,3-indandione rodenticides in 2 cases of anticoagulant toxicosis. Anecdotal evidence provided by the veterinarian in a case involving feedlot cows and physical evidence at the site of occurrence in a similar case involving lambs strongly implicated diphenadione (diphacinone; DP) in both instances. However, high performance liquid chromatography indicated chlorophacinone (CP), not DP, was present in the blood samples obtained from both cows and lambs. Intact 1,3-indandiones exhibit poor gas chromatographic properties, so procedures were developed for analysis by MS\/MS using a direct exposure probe for sample introduction. The EI mass spectra of DP and CP contained a base peak at m\/z 173, with molecular ions (M+) at m\/z 340 and m\/z 374 (Cl isotope cluster), respectively. Corresponding MS\/MS CAD parent ion spectra of m\/z 173 showed an ion of m\/z 340 for DP and 374 (Cl cluster) for CP. CAD analysis of the blood extracts showed a parent ion scan of m\/z 173 identical to that of CP, with the m\/z 374 (Cl cluster). (Additional evidence was obtained by MS\/MS examination of the CAD daughter ion spectrum of m\/z 374.) Blood extracts from the affected animals revealed CAD daughter ion spectra for m\/z 374 identical to that of reference CP. Positive confirmation of CP in both cases led to identification of the source of the toxicant and prevention of further animal exposures.<\/jats:p>","DOI":"10.1177\/104063879200400413","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:10:00Z","timestamp":1305216600000},"page":"441-446","source":"Crossref","is-referenced-by-count":23,"title":["Confirmation of Indandione Rodenticide Toxicoses by Mass Spectrometry\/Mass Spectrometry"],"prefix":"10.1177","volume":"4","author":[{"suffix":"Jr.","given":"W. Emmett","family":"Braselton","sequence":"first","affiliation":[{"name":"Animal Health Diagnostic Laboratory, Michigan State University, East Lansing, MI 48824"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regg D.","family":"Neiger","sequence":"additional","affiliation":[{"name":"Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD 57007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Poppenga","sequence":"additional","affiliation":[{"name":"Animal Health Diagnostic Laboratory, Michigan State University, East Lansing, MI 48824"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1992,10,1]]},"reference":[{"key":"bibr1-104063879200400413","doi-asserted-by":"publisher","DOI":"10.1021\/jf60197a011"},{"key":"bibr2-104063879200400413","author":"Chalermchaikit T","year":"1992","journal-title":"J Anal Toxicol"},{"key":"bibr3-104063879200400413","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80561-P"},{"key":"bibr4-104063879200400413","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2460\/ajvr.1989.50.04.546","volume":"50","author":"Ray AC","year":"1989","journal-title":"Am J Vet Res"},{"key":"bibr5-104063879200400413","first-page":"187","volume":"23","author":"Reynolds JD","year":"1980","journal-title":"Proc Annu Meet Am Assoc Vet Lab Diagn"},{"key":"bibr6-104063879200400413","doi-asserted-by":"publisher","DOI":"10.1021\/ac50048a002"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/104063879200400413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/104063879200400413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:32:34Z","timestamp":1777681954000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/104063879200400413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,10]]}},"alternative-id":["10.1177\/104063879200400413"],"URL":"https:\/\/doi.org\/10.1177\/104063879200400413","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}