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Of the 13 DR-2-infected pigs remaining free of foot-and-mouth disease (FMD), 2 pigs survived to 24 days without antibody to FMDV, despite constant contact with clinically infected pigs with FMD. Three other DR-2-infected pigs never developed FMD lesions but did develop low levels of antibody to FMDV by day 17. A group of larger pigs (in which DR-2 is less virulent) infected with DR.2 and then FMDV had a rapid but suppressed immune response to FMDV. Contact pigs introduced 3 days postinoculation and inoculated with FMDV only all became infected with ASFV by contact and died. This remarkably long lasting 1-way interference with FMD infection during acute and subacute African swine fever was not anticipated. Infection with ASFV may have blocked the initial target cells (possibly dendritic cells) necessary for establishment of FMDV infection.<\/jats:p>","DOI":"10.1177\/104063879500700105","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:18:45Z","timestamp":1305217125000},"page":"31-43","source":"Crossref","is-referenced-by-count":7,"title":["African Swine Fever Interference with Foot-and-Mouth Disease Infection and Seroconversion in Pigs"],"prefix":"10.1177","volume":"7","author":[{"given":"Douglas A.","family":"Gregg","sequence":"first","affiliation":[{"name":"Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, APHIS, USDA, Greenport, NY 11944"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Mebus","sequence":"additional","affiliation":[{"name":"Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, APHIS, USDA, Greenport, NY 11944"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald H.","family":"Schlafer","sequence":"additional","affiliation":[{"name":"New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"key":"bibr1-104063879500700105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb02453.x"},{"key":"bibr2-104063879500700105","first-page":"161","volume":"62","author":"Austyn JM","year":"1987","journal-title":"Immunology"},{"key":"bibr3-104063879500700105","first-page":"23","volume-title":"Epidermal Langerhans cells","author":"Breathnach SM","year":"1991"},{"key":"bibr4-104063879500700105","first-page":"1343","volume":"30","author":"Colgrove GS","year":"1969","journal-title":"Am J Vet Res"},{"key":"bibr5-104063879500700105","first-page":"641","volume":"58","author":"Croll AD","year":"1986","journal-title":"Immunology"},{"key":"bibr6-104063879500700105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01241270"},{"key":"bibr7-104063879500700105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01250313"},{"key":"bibr8-104063879500700105","first-page":"733","volume":"63","author":"Delay PD","year":"1965","journal-title":"Bull Off Int Epizoot"},{"key":"bibr9-104063879500700105","first-page":"811","volume":"18","author":"DeTray DE","year":"1957","journal-title":"Am J Vet Res"},{"key":"bibr10-104063879500700105","doi-asserted-by":"publisher","DOI":"10.1084\/jem.156.4.1222"},{"key":"bibr11-104063879500700105","volume-title":"Probit analysis: a statistical treatment of the sigmoid response curve","author":"Finney D J","year":"1952","edition":"2"},{"key":"bibr12-104063879500700105","doi-asserted-by":"publisher","DOI":"10.1007\/BF01309929"},{"key":"bibr13-104063879500700105","unstructured":"Gonzalez-Juarrero M, Laegreid WW, La Bonnardiere C, 1990, Studies on interferon production and effects of diverse types of interferon on African swine fever virus infection and swine leukocyte antigen (SLA) expression. 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