{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:01:46Z","timestamp":1792141306544,"version":"4.4.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>Malignant catarrhal fever (MCF) in cattle is generally associated with a short clinical course and a high case fatality rate (90\u201395%). The lesions in cattle that survive acute MCF for a prolonged period or appear to recover have not been documented. In a naturally occurring outbreak of MCF in a herd of beef cattle in Wyoming, 7 of 84 yearling heifers (8.3% of replacement herd) and 2 of 230 cows (0.9% of cow herd) developed clinical signs of pyrexia, mucopurulent discharge, bilateral keratitis, and weight loss following contact with ewes that had lambed 34\u201362 days earlier. Six of 9 affected cattle were examined postmortem following clinical signs (CS) that developed 2\u2013150 days earlier. Three cattle with CS for \u226439 days had lesions of regional lymphadenopathy and widespread severe segmental lymphoid arteritis-phlebitis that were typical of acute MCF, and proliferative intimal lesions were present in a small proportion of arteries at days 20 and 39 of CS. By contrast, 3 cattle that survived to 90, 105, and 150 days after clinical onset had distinctive arterial lesions in multiple organs, characterized by proliferative concentric fibrointimal plaques, disrupted inner elastic lamina, focally atrophic tunica media, and vasculitis of variable severity. Immunohistochemical and ultrastructural examination of intimal plaques identified the predominant cellular component to be smooth muscle cells with a contractile phenotype. No viral structures were seen. Serologic studies, using a competitive inhibition enzyme-linked immunosorbent assay (CI-ELISA) that detects antibody to an epitope broadly conserved among isolates of the MCF virus, found that 2 chronically affected cattle were serologically positive between days 42 and 100 of CS, with seroconversion in 1 animal between days 52 and 73 of CS. Seroprevalence was 7.9% in the 76 remaining healthy animals of the replacement heifer herd and 40% (75% in adult sheep and 4% in lambs) in the in-contact sheep flock 77 days after onset of CS in the index case. This episode suggests that, in addition to the common and well recognized acute form of MCF in cattle, this viral infection encompasses a disease spectrum that includes chronic disease and partial to \u201ccomplete\u201d clinical recovery, and in recovered animals chronic obliterative arteriopathy is the preeminent lesion. The MCF CI-ELISA may be helpful in identifying such cattle and in epidemiologic studies of MCF outbreaks.<\/jats:p>","DOI":"10.1177\/104063879500700118","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:18:45Z","timestamp":1305217125000},"page":"108-121","source":"Crossref","is-referenced-by-count":43,"title":["Chronic Generalized Obliterative Arteriopathy in Cattle: A Sequel to Sheep-Associated Malignant Catarrhal Fever"],"prefix":"10.1177","volume":"7","author":[{"given":"Donal","family":"O'Toole","sequence":"first","affiliation":[{"name":"Wyoming State Veterinary Laboratory, 1174 Snowy Range Road, Laramie, WY 82070"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Animal Diseases Research Unit, USDA, Agricultural Research Service, Pullman, WA 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