{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:52:31Z","timestamp":1777859551956,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Pediatr Oncol Nurs"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    Sickle cell disease (SCD) is an inherited disorder in which sickled red blood cells occlude the small vessels of the body, reducing oxygen delivery to tissues and ultimately negatively affecting many of the body\u2019s major organs. Hydroxyurea has proven beneficial in the treatment of SCD and prevention of disease-related complications. The 2014 guidelines put forth by the National Heart, Lung, and Blood Institute recommend hydroxyurea treatment in infants 9 months and older, children, and adolescents with SCD-SS or SCD-S\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    thalassemia regardless of clinical severity. This is a change from the 2002 guidelines in which hydroxyurea was recommended for adolescents and children with SCD-SS or SCD-S\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    thalassemia with frequent episodes of pain, a history of acute chest syndrome, severe and symptomatic anemia or other severe vaso-occlusive events. Nurses play a critical role in working with patients and families to provide education, guidance, and support to improve compliance to mitigate the long-term effects of SCD.\n                  <\/jats:p>","DOI":"10.1177\/1043454215614962","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T21:18:42Z","timestamp":1448572722000},"page":"339-344","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hydroxyurea in Pediatric Patients With Sickle Cell Disease"],"prefix":"10.1177","volume":"33","author":[{"given":"Allison L.","family":"Rees","sequence":"first","affiliation":[{"name":"University of Pennsylvania School of Nursing, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"bibr1-1043454215614962","first-page":"145","volume":"5","author":"Al-Anazi K. 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Retrieved from http:\/\/www.nhlbi.nih.gov\/health-pro\/guidelines\/sickle-cell-disease-guidelines"},{"key":"bibr12-1043454215614962","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24381"},{"key":"bibr13-1043454215614962","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24178"},{"key":"bibr14-1043454215614962","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182114c54"},{"key":"bibr15-1043454215614962","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-419879"},{"key":"bibr16-1043454215614962","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0177"},{"key":"bibr17-1043454215614962","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60355-3"},{"key":"bibr18-1043454215614962","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-146852"}],"container-title":["Journal of Pediatric Oncology Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1043454215614962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1043454215614962","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1043454215614962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:33:03Z","timestamp":1777509183000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1043454215614962"}},"subtitle":["What Nurses Need to Know"],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1177\/1043454215614962"],"URL":"https:\/\/doi.org\/10.1177\/1043454215614962","relation":{},"ISSN":["1043-4542","1532-8457"],"issn-type":[{"value":"1043-4542","type":"print"},{"value":"1532-8457","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]}}}