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An electronic search of 6 databases using publication years 2000-2015 and multiple professional organizations and clinical resources was conducted. Evidence sources were reviewed for topic applicability. Each of the final 23 sources was appraised by 2 team members. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) system was used to assign a quality and strength rating for each recommendation. Multiple recommendations were developed: 4 relating to nurse monitoring of patients during and after drug administration, 8 guiding hypersensitivity reaction management, and 4 concerning patient\/family educational content. These strong recommendations were based on moderate, low, or very-low-quality evidence. Several recommendations relied on generalized drug hypersensitivity guidelines. Additional research is needed to safely guide PEG-asparaginase monitoring, hypersensitivity reaction management, and patient\/family education. Nurses administering PEG-asparaginase play a critical role in the early identification and management of hypersensitivity reactions.<\/jats:p>","DOI":"10.1177\/1043454217713455","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T03:19:00Z","timestamp":1497064740000},"page":"387-396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["From the Children\u2019s Oncology Group: Evidence-Based Recommendations for PEG-Asparaginase Nurse Monitoring, Hypersensitivity Reaction Management, and Patient\/Family Education"],"prefix":"10.1177","volume":"34","author":[{"given":"Deborah","family":"Woods","sequence":"first","affiliation":[{"name":"Washington University, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Winchester","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Towerman","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Gettinger","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Carey","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Timmermann","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Langley","sequence":"additional","affiliation":[{"name":"Washington University, St. Louis, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Browne","sequence":"additional","affiliation":[{"name":"St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,10]]},"reference":[{"key":"bibr1-1043454217713455","doi-asserted-by":"publisher","DOI":"10.1188\/14.CJON.E107-E112"},{"key":"bibr2-1043454217713455","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31828e5471"},{"key":"bibr3-1043454217713455","unstructured":"Bechwith C., Wheeler M., Jensen L. 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