{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:53:40Z","timestamp":1784832820626,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Pediatr Oncol Nurs"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Adherence to oral medications during maintenance therapy is essential for pediatric patients with acute lymphoblastic leukemia. Self-reported or electronic monitoring of adherence indicate suboptimal adherence, particularly among particular sociodemographic groups. This study used medication refill records to examine adherence among a national sample of pediatric patients with acute lymphoblastic leukemia. Patients in a national claims database, aged 0 to 21 years with a diagnosis of acute lymphoblastic leukemia and in the maintenance phase of treatment, were included. Medication possession ratios were used as measures of adherence. Overall adherence and adherence by sociodemographic groups were examined. Adherence rates were 85% for 6-mercaptopurine and 81% for methotrexate. Adherence was poorer among patients 12 years and older. Oral medication adherence rates were suboptimal and similar to or lower than previously documented rates using other methods of assessing adherence. Refill records offer a promising avenue for monitoring adherence. Additional work to identify groups most at-risk for poor adherence is needed. Nurses are well positioned to routinely monitor for medication adherence and to collaborate with the multidisciplinary team to address barriers to adherence.<\/jats:p>","DOI":"10.1177\/1043454217741877","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T06:45:38Z","timestamp":1512024338000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Adherence to Oral Medications During Maintenance Therapy Among Children and Adolescents With Acute Lymphoblastic Leukemia: A Medication Refill Analysis"],"prefix":"10.1177","volume":"35","author":[{"given":"Yelena P.","family":"Wu","sequence":"first","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Stenehjem","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"},{"name":"Department of Pharmacy Practice and Pharmaceutical Sciences, University of Minnesota, College of Pharmacy, Duluth, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri A.","family":"Linder","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"},{"name":"Primary Children\u2019s Hospital, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget Grahmann","family":"Parsons","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Mooney","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark N.","family":"Fluchel","sequence":"additional","affiliation":[{"name":"University of Utah, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"bibr1-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.12089"},{"key":"bibr2-1043454217741877","unstructured":"American Cancer Society. (2016a). Cancer facts & figures 2016. Atlanta, GA: Author. Retrieved from https:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-and-statistics\/annual-cancer-facts-and-figures\/2016\/cancer-facts-and-figures-2016.pdf"},{"key":"bibr3-1043454217741877","unstructured":"American Cancer Society. (2016b). Survival rates for childhood leukemias. Retrieved from http:\/\/www.cancer.org\/cancer\/leukemiainchildren\/detailedguide\/childhood-leukemia-survival-rates"},{"key":"bibr4-1043454217741877","unstructured":"American Cancer Society. (2016c). What are the key statistics for childhood leukemia? Retrieved from http:\/\/www.cancer.org\/cancer\/leukemiainchildren\/detailedguide\/childhood-leukemia-key-statistics"},{"key":"bibr5-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3280"},{"key":"bibr6-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-01-552166"},{"key":"bibr7-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.38.9924"},{"key":"bibr8-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.22.2802"},{"key":"bibr9-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00213.x"},{"key":"bibr10-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1097\/mop.0000000000000434"},{"key":"bibr11-1043454217741877","unstructured":"High-Value Health Care Project. (2010). Indirect estimation of race and ethnicity: An interim strategy to measure population level health care disparities. Retrieved from http:\/\/www.healthqualityalliance.org\/userfiles\/RANDissuebrief031810.pdf"},{"key":"bibr12-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.12.011"},{"key":"bibr13-1043454217741877","unstructured":"Inovalon Inc. (2015). Medical Outcomes Research for Effectiveness and Economics Registry (MORE2 Registry). Retrieved from http:\/\/www.inovalon.com\/howwehelp\/more2-registry"},{"key":"bibr14-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3134"},{"key":"bibr15-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(10)70069-3"},{"key":"bibr16-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.4.365"},{"key":"bibr17-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2011.02.006"},{"key":"bibr18-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1159\/000437305"},{"key":"bibr19-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-013-9865-x"},{"key":"bibr20-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.450"},{"key":"bibr21-1043454217741877","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2012.693150"},{"key":"bibr22-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2015.08.007"},{"key":"bibr23-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1635"},{"key":"bibr24-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsu038"},{"key":"bibr25-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsh005"},{"key":"bibr26-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocv054"},{"key":"bibr27-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsv044"},{"key":"bibr28-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0570-3"},{"key":"bibr29-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jst093"},{"key":"bibr30-1043454217741877","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20004"},{"key":"bibr31-1043454217741877","doi-asserted-by":"publisher","DOI":"10.2165\/11537400-000000000-00000"},{"key":"bibr32-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00268-5"},{"key":"bibr33-1043454217741877","doi-asserted-by":"publisher","DOI":"10.2147\/ppa.s37811"},{"key":"bibr34-1043454217741877","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21219"},{"key":"bibr35-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1103069"},{"key":"bibr36-1043454217741877","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000034"}],"container-title":["Journal of Pediatric Oncology Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1043454217741877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1043454217741877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1043454217741877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:33:20Z","timestamp":1777509200000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1043454217741877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,30]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1177\/1043454217741877"],"URL":"https:\/\/doi.org\/10.1177\/1043454217741877","relation":{},"ISSN":["1043-4542","1532-8457"],"issn-type":[{"value":"1043-4542","type":"print"},{"value":"1532-8457","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,30]]}}}