{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:43:08Z","timestamp":1788903788889,"version":"build-2803163510"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T00:00:00Z","timestamp":1562976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U10CA180886; PI-Adamson"],"award-info":[{"award-number":["U10CA180886; PI-Adamson"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Pediatr Oncol Nurs"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Repeated invasive and painful procedures are often necessary components of pediatric cancer treatment. Adequate pain control during procedures is essential; however, procedure-related pain may be underestimated and undertreated. Currently, there is not a standard approach for the appropriate level of sedation to manage procedure-related pain in children with cancer. A team was assembled to review the evidence and develop recommendations to determine the appropriate level of sedation necessary for pain control in patients undergoing pediatric oncology procedures. After a systematic search of the literature, 15 research-based articles were synthesized and critically appraised. A recommendation was made related to the level of sedation utilized for bone marrow aspirates and bone marrow biopsies. There is a need for further research related to the necessary level of sedation for patients undergoing pediatric oncology procedures.<\/jats:p>","DOI":"10.1177\/1043454219858610","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T08:21:51Z","timestamp":1563006111000},"page":"6-20","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Evidence-Based Recommendations for the Appropriate Level of Sedation to Manage Pain in Pediatric Oncology Patients Requiring Procedures: A Systematic Review From the Children\u2019s Oncology Group"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5038-803X","authenticated-orcid":false,"given":"Elizabeth A.","family":"Duffy","sequence":"first","affiliation":[{"name":"The University of Michigan School of Nursing, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Adams","sequence":"additional","affiliation":[{"name":"Dell Children\u2019s Medical Center, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton P.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Nursing, Baltimore MD, USA"},{"name":"Herman and Walter Samuelson Children\u2019s Hospital at Sinai, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Fisher","sequence":"additional","affiliation":[{"name":"Aflac Cancer and Blood Disorder Center, Atlanta, GA, USA"},{"name":"Clemson University, Clemson, SC, USA"},{"name":"Prisma Health, Greenville, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Misasi","sequence":"additional","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"McCollum","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,13]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20186"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002043"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/jpeds.2012.06.056"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01233.x"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)90018-9"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23250"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000028"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.3768\/rtipress.2015.bk.0014.1509"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2008.01006.x"},{"key":"e_1_3_4_11_1","unstructured":"Children\u2019s Oncology Group. (2010). Risk adapted chemotherapy in treating younger patients with newly diagnosed standard-risk acute lymphoblastic leukemia or localized b-lineage lymphoblastic lymphoma (ClinicalTrials.gov Identifier NCT01190930). Retrieved from https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT01190930?term=AALL0932&cond=Pediatric+Leukemia%2C+Acute+Lymphocytic&rank=1"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2006.03.007"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsm103"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.3.253"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2009.00701.x"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4542(97)90061-8"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01407.x"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_3_4_20_1","volume-title":"Pain management in children with cancer","author":"Hockenberry-Eaton M. J.","year":"1999","unstructured":"Hockenberry-Eaton M. J., Barerra P., Brown M., Bottomley S. J., O\u2019Neill J. B. (1999). Pain management in children with cancer. Houston: Texas Cancer Council."},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181f46a65"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C088"},{"key":"e_1_3_4_23_1","unstructured":"Howlander N. Noone A. M. Krapcho M. Garshell J. Neymen N. Altekruse S. F. Cronin K. A. (Eds.). (2013). SEER Cancer Statistics Review 1975-2010. Bethesda MD: National Cancer Institute. Retrieved from https:\/\/seer.cancer.gov\/csr\/1975_2010\/"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20567"},{"key":"e_1_3_4_25_1","volume-title":"Crossing the quality chasm: A new health system for the 21st century","author":"Institute of Medicine","year":"2001","unstructured":"Institute of Medicine. (2001). Crossing the quality chasm: A new health system for the 21st century (Committee on Quality of Health Care in America). Washington, DC: National Academies Press."},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.1.59"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0882-5963(96)80081-9"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2013.12.004"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24415"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2010.01.009"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4544"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1088"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-322909"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.86.5.814"},{"key":"e_1_3_4_35_1","first-page":"293","article-title":"The FLACC: A behavioral scale for scoring postoperative pain in young children","volume":"23","author":"Merkel S. I.","year":"1997","unstructured":"Merkel S. I., Voepel-Lewis T., Shayevitz J. R., Malviya S. (1997). The FLACC: A behavioral scale for scoring postoperative pain in young children. Pediatric Nursing, 23, 293-297.","journal-title":"Pediatric Nursing"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed1000097"},{"key":"e_1_3_4_37_1","first-page":"358","article-title":"The clinical effect of fentanyl in comparison with ketamine analgesic effect for oncology procedures in children: A randomized, double-blinded, crossover","volume":"98","author":"Monsereenusorn C.","year":"2015","unstructured":"Monsereenusorn C., Rujkijyanont P., Traivaree C. (2015). The clinical effect of fentanyl in comparison with ketamine analgesic effect for oncology procedures in children: A randomized, double-blinded, crossover. Journal of the Medical Association of Thailand, 98, 358-363.","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21669"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.1999.9120280.x"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36721-9"},{"key":"e_1_3_4_41_1","first-page":"816","volume-title":"Pediatrics","volume":"86","author":"Schechter N.","year":"1990","unstructured":"Schechter N., Altman A., Weisman S. (1990). Report of the consensus conference on the management of pain in childhood cancer. Pediatrics, 86, 816-834."},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010050034319"},{"key":"e_1_3_4_44_1","first-page":"19","article-title":"The factors of ketamine that affect sedation in children with oncology procedures: Parent satisfaction perspective","volume":"97","author":"Traivaree C.","year":"2014","unstructured":"Traivaree C., Jindakam W., Monsereenusom C., Rujkijyanont P., Lumkul R. (2014). The factors of ketamine that affect sedation in children with oncology procedures: Parent satisfaction perspective. Journal of the Medical Association of Thailand, 97, 19-24.","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.152.2.147"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25236"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1677-0_2"}],"container-title":["Journal of Pediatric Oncology Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1043454219858610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1043454219858610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1043454219858610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:33:33Z","timestamp":1777509213000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1043454219858610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,13]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/1043454219858610"],"URL":"https:\/\/doi.org\/10.1177\/1043454219858610","relation":{},"ISSN":["1043-4542","1532-8457"],"issn-type":[{"value":"1043-4542","type":"print"},{"value":"1532-8457","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,13]]}}}