{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:47:38Z","timestamp":1777859258769,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1994,10,1]],"date-time":"1994-10-01T00:00:00Z","timestamp":780969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Oncol Nurs"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:p>Central line thrombus is a well recognized complication of long-term venous access devices. Oncology nurses are key players in the recognition and treatment of central line thrombus. An understanding of the mechanisms and interrelated variables in the formation of thrombus, as well as knowledge of treatment alternatives is essential for the pediatric oncology nurse. Described here are some of the causes and contributing factors in the development of central line thrombus. In addition, a case study is used to examine an unusual presentation and treatment of a complicated central line thrombus. Issues discussed include (1) the effects of L-asparaginase and its analogs on clotting mechanisms; (2) the effects of suboptimal placement of the catheter tip on thrombus formation; (3) the diagnosis of a intracardiac central line related thrombus by means of routine echocardiogram in an asymptomatic patient; and (4) the necessity of cardiac surgery as an intervention for large right atrial thrombus.<\/jats:p>","DOI":"10.1177\/104345429401100405","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T14:12:54Z","timestamp":1193235174000},"page":"146-151","source":"Crossref","is-referenced-by-count":3,"title":["Detection and Treatment of Central Line Thrombus: A Case Study"],"prefix":"10.1177","volume":"11","author":[{"given":"Kathy","family":"Ruble","sequence":"first","affiliation":[{"name":"Pediatric Oncology Clinical Nurse Specialist, CMSC 907, Johns Hopkins Hospital, 600 N Wolfe, Baltimore, MD 21287"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Lawrence-Kane","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Brown","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital, Baltimore, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930440112"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930450208"},{"key":"atypb3","first-page":"495","volume":"169","author":"Harvey WH","year":"1989","journal-title":"Surg Gynecol Obstet"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.7.1255"},{"key":"atypb5","first-page":"963","volume":"83","author":"Bagnall HA","year":"1991","journal-title":"Pediatrics"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1985.01390350023006"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830310411"},{"key":"atypb8","first-page":"100","volume":"13","author":"Wachs T.","year":"1990","journal-title":"J Intraven Nurs"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(84)80098-6"},{"key":"atypb10","unstructured":"Soff GA, Rosenberg RD: Physiology of hemostasis: The fluid phase, in Nathan DG, Oski FA (eds): Hematology of Infancy and Childhood. Philadelphia, PA, Saunders, 1992, PP 1534-1557"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199210153271611"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2483"},{"key":"atypb13","first-page":"543","volume":"17","author":"Brown-Smith JK","year":"1990","journal-title":"Oncol Nurs Forum"},{"key":"atypb14","unstructured":"US Federal Drug Administration Drug Bulletin: Precaution necessary with central venous catheters. 19:15-16, 1989"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/104345429301000238"},{"key":"atypb16","first-page":"32","volume":"10","author":"Gralnick HR","year":"1969","journal-title":"Proc Am Assoc Cancer Res"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80536-2"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661178"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830320105"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91139-3"},{"key":"atypb21","first-page":"273","volume":"48","author":"Bendich A.","year":"1982","journal-title":"Clin Exper Immun"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801001)46:7<1548::AID-CNCR2820460709>3.0.CO;2-7"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80535-0"},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1542\/peds.66.6.943","volume":"66","author":"Lockman LA","year":"1982","journal-title":"Pediatr"}],"container-title":["Journal of Pediatric Oncology Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/104345429401100405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/104345429401100405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:27:58Z","timestamp":1777508878000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/104345429401100405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1177\/104345429401100405"],"URL":"https:\/\/doi.org\/10.1177\/104345429401100405","relation":{},"ISSN":["1043-4542","1532-8457"],"issn-type":[{"value":"1043-4542","type":"print"},{"value":"1532-8457","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}