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BAs exert complex physiological effects through their interaction with nuclear receptors, such as farnesoid X receptor or cell membrane receptor Takeda G protein-coupled receptor 5. Disruption of BA transport and homeostasis results in the accumulation of BAs and elevated concentrations in the systemic circulation. This contributes to the pathogenesis of cholestatic disorders and is implicated in a variety of liver diseases, including primary biliary cholangitis and primary sclerosing cholangitis. In the context of cholestatic liver injury, BAs interact with parenchymal hepatocytes and nonparenchymal cells, leading to hepatocyte apoptosis, activation of hepatic stellate cells, and the initiation of inflammatory responses. Identifying key cellular and molecular components involved in this interaction may contribute to the development of potential therapies for cholestatic liver diseases. In this article, we provide a summary of the molecular mechanisms underlying BA-mediated interactions with various cell types in the cholestatic liver and discuss therapeutic strategies targeting BA pathways. We anticipate that a deeper understanding of these interactions will enable the formulation of novel strategies for the treatment of cholestatic liver injury.<\/jats:p>","DOI":"10.1177\/10445498251359370","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:36:02Z","timestamp":1757687762000},"page":"502-511","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Bile Acid-Mediated Interactions with Various Cell Types in the Cholestatic Liver"],"prefix":"10.1177","volume":"44","author":[{"given":"Guanyi","family":"He","sequence":"first","affiliation":[{"name":"Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qing","sequence":"additional","affiliation":[{"name":"Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China."},{"name":"Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China."},{"name":"MOE Key Laboratory of Bioorganic Phosphorus Chemistry &amp; Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"issue":"2","key":"e_1_3_4_2_1","article-title":"TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload","volume":"3","author":"Bidault-Jourdainne V","year":"2021","unstructured":"Bidault-Jourdainne V, , Merlen G, , Glenisson M, et al. 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