{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:21:09Z","timestamp":1777944069600,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    Breast cancer is the most diagnosed cancer in women and the second leading cause of cancer-related mortality worldwide. Advances in genetic technology have highlighted the heterogeneity of breast cancer, composed of various biological subtypes, with genetic profiling playing a crucial role in predicting chemotherapy response. This underscores the importance of identifying sensitive diagnostic and prognostic markers for early detection and developing more efficient targeted therapies. Among these, survivin, a protein linked to apoptosis inhibition and cell cycle regulation, is strongly expressed in various cancers, including breast cancer, where its overexpression is associated with poor prognosis and reduced survival rates. To analyze the effects of survivin gene inhibition in a triple-negative breast cancer (TNBC) model. The MDA-MB-231 cell line was stably transfected with short hairpin RNA targeting survivin, and the inhibition was validated via RT-qPCR and Western blot. Morphological evaluation, proliferation and migration assays, and a differential gene expression analysis using the GeneChip\u2122 Human Gene 2.0 ST Array were performed. Statistical analyses were conducted with GraphPad Prism version 8 and Transcriptome Analysis Console. Survivin-inhibited MDA-MB-231-KD cells exhibited evident morphological changes, reduced migration capacity, and altered expression of genes such as\n                    <jats:italic toggle=\"yes\">BCL2, COX1, COX2, VGF, BIR2<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">CDC20<\/jats:italic>\n                    , involved in key cancer signaling pathways. Inhibition of survivin in this TNBC model induces critical cellular changes and significantly alters gene expression associated with tumor progression, highlighting its potential as a therapeutic target.\n                  <\/jats:p>","DOI":"10.1177\/10445498261421790","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:32:44Z","timestamp":1773286364000},"page":"214-225","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Compensatory Gene Regulation Following Survivin Inhibition in MDA-MB-231 Cells"],"prefix":"10.1177","volume":"45","author":[{"given":"Manuel Antonio","family":"Mart\u00ednez-Sifuentes","sequence":"first","affiliation":[{"name":"Department of Reproductive Biology, Biomedical Research Center, Universidad Aut\u00f3noma de Coahuila, Torreon City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Ramos-Trevi\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, Biomedical Research Center, Universidad Aut\u00f3noma de Coahuila, Torreon City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Espinosa-Castilla","sequence":"additional","affiliation":[{"name":"Department of Basic Research, Functional Cancer Genomics Laboratory, Instituto Nacional de Medicina Gen\u00f3mica, Mexico City, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila Adela","family":"Villa-Cedillo","sequence":"additional","affiliation":[{"name":"Department of Histology, Faculty of Medicine, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey City, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iliana","family":"Encino-Ortega","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, Biomedical Research Center, Universidad Aut\u00f3noma de Coahuila, Torreon City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Alejandra","family":"Mu\u00f1oz-Dominguez","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, Biomedical Research Center, Universidad Aut\u00f3noma de Coahuila, Torreon City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Ruiz-Flores","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Medicine, Biomedical Research Center, Universidad Aut\u00f3noma de Coahuila, Torreon City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-7065","authenticated-orcid":false,"given":"Jos\u00e9 Anselmo","family":"Hern\u00e1ndez-Ibarra","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, Biomedical Research Center, Universidad Aut\u00f3noma de Coahuila, Torreon City, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MSEC.2019.109928"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS14215180"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12551-017-0392-1"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/FMOLB.2022.836417"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2023.2286101"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/BS.IRCMB.2021.02.017"},{"issue":"4","key":"e_1_3_3_8_1","first-page":"675","article-title":"PI3K inhibition sensitize the cisplatin-resistant human ovarian cancer cell OVCAR3 by induction of oxidative stress","volume":"10","author":"Baghal-Sadriforoush S","year":"2022","unstructured":"Baghal-Sadriforoush S, , Bagheri M, , Rad IA, et al. 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