{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:10:04Z","timestamp":1779891004245,"version":"3.53.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    This study investigated the influence of homeopathic medicines (HMs) on the\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    behavior of stem cells from human exfoliated deciduous teeth (SHED). The HMs\n                    <jats:italic toggle=\"yes\">Symphytum officinale<\/jats:italic>\n                    (SO),\n                    <jats:italic toggle=\"yes\">Calcarea carbonica<\/jats:italic>\n                    (CC), and\n                    <jats:italic toggle=\"yes\">Calcarea phosphorica<\/jats:italic>\n                    (CP) were evaluated, along with a vehicle control (V), using cells from a single donor in passages 4 (P4) and 5 (P5). Cellular responses were assessed using Neutral Red (viability-related activity), Crystal Violet (adherent cell density), MTT (metabolic activity), and scanning electron microscopy (SEM). Across assays, consistent modulation of cellular behavior was observed, particularly in P5 at 72 h. Neutral Red uptake increased over time in P4 and showed treatment-dependent responses in P5. Crystal Violet indicated increased adherent cell density, with higher values in P5 compared to P4. MTT demonstrated increased metabolic activity at 72 h, especially in P5. SEM analysis confirmed these findings, showing that cells treated with SO, CC, and CP remained well adhered and spread, with increased cell density and more compact organization. In contrast, the vehicle group exhibited reduced cell density and altered morphology. Overall, the tested HMs were associated with measurable changes in SHED behavior without evident adverse effects. These findings should be interpreted as exploratory and require further validation.\n                  <\/jats:p>","DOI":"10.1177\/10445498261444142","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:00:17Z","timestamp":1776744017000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Homeopathic Medicines on Dental Stem Cells: An Experimental Study"],"prefix":"10.1177","volume":"45","author":[{"given":"Marli Cristina","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Biotechnology, School of Health Sciences, Positivo University, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thain\u00e1 Beatriz","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Health Sciences, Positivo University, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeferson Luis de Oliveira","family":"Stroparo","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Health Sciences, Positivo University, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Cunha da Fonseca","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Cell Molecular and Biology Science, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisley Janowski","family":"Spisila","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Science, Biochemistry, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, University Veiga de Almeida, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosy de Oliveira","family":"Nardi","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry, University of Volta Redonda, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Castiglia","family":"Gonzaga","sequence":"additional","affiliation":[{"name":"Department of Dentistry, School of Health Sciences, Positivo University, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia Regina Cavichiolo","family":"Franco","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Science, Biochemistry, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira Pedroso","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Curityba 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Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2012.10.005"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.08.117"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01666038"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S58805"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112329"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.709711"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(86)90314-3"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6324912"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2020.06.001"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.08.077"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-9-1-63"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/app11104478"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_3_2_16_1","volume-title":"Brazilian 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