{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:46:34Z","timestamp":1782949594879,"version":"3.54.5"},"reference-count":28,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Policy-Guided Projects of Yantai Science and Technology Innovation Development Plan","award":["2024YD016"],"award-info":[{"award-number":["2024YD016"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["DNA and Cell Biology"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    The purpose of this work was to examine the function of fibroblast growth factor 18 (FGF18) in rat myocardial ischemia-reperfusion injury (MIRI) and elucidate its relationship to mitochondrial function through the Sirtuin 1\/peroxisome proliferator-activated receptor gamma coactivator 1 (SIRT1\/PGC-1\u03b1) pathway. To evaluate myocardial infarct size, pathological alterations, cardiomyocyte injury, mitochondrial state, oxidative stress, and SIRT1\/PGC-1\u03b1 protein expression, FGF18-knockdown and FGF18-overexpression rat MIRI models were created. H9c2 cardiomyocytes were used to create an\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    hypoxia-reoxygenation (H\/R) model, and FGF18-overexpressing H9c2 cells were given the SIRT1 inhibitor EX-527. We detected the effects of FGF18-mediated regulation of the SIRT1\/PGC-1\u03b1 pathway on H\/R-induced alterations in H9c2 cells, including cell viability, mitochondrial reactive oxygen species (ROS) production, mitochondrial membrane potential, apoptotic rate, and the protein expression of FGF18, SIRT1, PGC-1\u03b1, and mitofusin 1 (Mfn1). Furthermore, we performed a protein immunoprecipitation (IP)-protein acetylation assay to determine whether FGF18 influences the acetylation level of PGC-1\u03b1 through the regulation of SIRT1. Results showed that FGF18 overexpression upregulated SIRT1\/PGC-1\u03b1\/Mfn1 expression, improved mitochondrial function, reduced oxidative stress, and enhanced H9c2 survival under H\/R, while FGF18 knockdown had opposite effects. Moreover, FGF18 overexpression inhibited H\/R-induced PGC-1\u03b1 acetylation, and SIRT1 inhibition abrogated FGF18-mediated protective effects. Collectively, FGF18 attenuates rat myocardial MIRI by alleviating oxidative stress and regulating mitochondrial homeostasis through SIRT1-mediated deacetylation of PGC-1\u03b1.\n                  <\/jats:p>","DOI":"10.1177\/10445498261458185","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:50:51Z","timestamp":1781592651000},"page":"389-400","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibroblast Growth Factor 18 Regulates Mitochondrial Function to Alleviate Myocardial Ischemia-Reperfusion Injury in Rats"],"prefix":"10.1177","volume":"45","author":[{"given":"Haijiao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Coronary Care Unit, Yantaishan Hospital, Yantai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Shouguang Hospital of Traditional Chinese Medicine, Weifang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4144-9789","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of the First Ward of Cardiovascular Medicine, Yantaishan Hospital, Yantai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.010"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36895-1"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.124043"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11497"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03391-z"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0302407"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106957"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.06.024"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.108492"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0005"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02733-1"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154122"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5554569"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186x.2022.2091577"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.118.039262"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12595"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111478"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13734"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.065"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.113888"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28255"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41800-x"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1320"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202401238R"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.04.165"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.12.003"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2024.0892"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9090858"}],"container-title":["DNA 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