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At its core, any single signal transduction pathway may be understood as classic Information Theory, adapted as an open system such that, because of networking, the \"receiver\" is presented with more information than was initially signaled by the \"source\". Over 40 years ago, Waddington presented his \"Epigenetic Landscape\" as a metaphor for the hierarchical nature of embryogenesis. Mathematically, Waddington's landscape may be modeled as a neural net. The \"black box\" of the neural net is an interacting network of signal transduction pathways (using hormones, growth factors, cytokines, neurotransmitters, and others) which inform the Boolean logic gates. An emerging theme in developmental biology is that defined sets of epigenetic circuits are used in multiple places, at multiple times, for similar and sometimes different purposes during organogenesis. As we show here, submandibular gland embryonic and fetal development is a splendid paradigm of these epigenetic circuits and their phenotypic outcomes, such as branching and lumen formation. <\/jats:p>","DOI":"10.1177\/10454411000110020401","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:40:32Z","timestamp":1231461632000},"page":"199-215","source":"Crossref","is-referenced-by-count":85,"title":["Mouse Submandibular Gland Morphogenesis: a Paradigm for Embryonic Signal Processing"],"prefix":"10.1177","volume":"11","author":[{"given":"Michael","family":"Molnick","sequence":"first","affiliation":[{"name":"Laboratory for Developmental Genetics, DEN-4266, MC-0641, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Jaskoll","sequence":"additional","affiliation":[{"name":"Laboratory for Developmental Genetics, DEN-4266, MC-0641, University of Southern California, 925 W. 34th Street, Los Angeles, CA 90089-0641, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199611)207:3<281::AID-AJA5>3.0.CO;2-D"},{"key":"atypb2","unstructured":"Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson JD (1994). 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