{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:49:27Z","timestamp":1789505367807,"version":"build-2803163510"},"reference-count":83,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Reviews in Oral Biology &amp; Medicine"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p> Bone has considerable potential for repair as illustrated by the phenomenon of fracture healing. Repair and regeneration of bone recapitulate the sequential stages of development. It is well known that demineralized bone matrix has the potential to induce new bone formation locally at a heterotopic site of implantation. The sequential development of bone is reminiscent of endochondral bone differentiation during bone development. The collagenous matrix-induced bone formation is a prototype model for matrix-cell interactions in vivo. The developmental cascade includes migration of progenitor cells by chemotaxis, attachment of cells through fibronectin, proliferation of mesenchymal cells, and differentiation of bone. The bone inductive protein, osteogenin, was isolated by heparin affinity chromatography. Osteogenin initiates new bone formation and is promoted by other growth factors. Recently, the genes for osteogenin and related bone morphogenetic proteins were cloned and expressed. Recombinant osteogenin is osteogenic in vivo. The future prospects for bone induction are bright, and this is an exciting frontier with applications in oral and orthopaedic surgery. <\/jats:p>","DOI":"10.1177\/10454411920030010101","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T18:53:56Z","timestamp":1483642436000},"page":"1-14","source":"Crossref","is-referenced-by-count":46,"title":["Growth and Morphogenetic Factors in Bone Induction: Role of Osteogenin and Related Bone Morphogenetic Proteins in Craniofacial and Periodontal Bone Repair"],"prefix":"10.1177","volume":"3","author":[{"given":"Ugo","family":"Ripamonti","sequence":"first","affiliation":[{"name":"Bone Cell Biology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hari Reddi","sequence":"additional","affiliation":[{"name":"Bone Cell Biology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1992,1,1]]},"reference":[{"key":"atypb1","unstructured":"Reddi, A.H., Extracellular matrix and development, in Extracellular Matrix Biochemistry, Piez, K. A. and Reddi, A. H., Eds., Elsevier, New York, 1984, 375."},{"key":"atypb2","unstructured":"Reddi, A.H., Regulation of bone differentiation by local and systemic factors, in Bone and Mineral Research, Vol. 3, Peck, W. A., Ed., Elsevier Science Publishers, Amsterdam, 1985, 27."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001830102"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.3109\/03008208909023901"},{"key":"atypb5","doi-asserted-by":"crossref","unstructured":"Urist, M.R., Bone: formation by autoinduction, Science, 159, 893, 1965.","DOI":"10.1126\/science.150.3698.893"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.6.1601"},{"key":"atypb7","doi-asserted-by":"crossref","unstructured":"Reddi, A.H., Cell biology and biochemistry of endochondral bone development, Collagen Rel. Res., 1, 209, 1981.","DOI":"10.1016\/S0174-173X(81)80021-0"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7109"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"key":"atypb10","doi-asserted-by":"crossref","unstructured":"Luyten, F.P., Cunningham, N.S., Ma, S., Muthukumaran, N., Hammonds, R.G., Nevins, W.B., Wood, W.I., and Reddi, A.H., Purification and partial amino acid sequence of osteogenin, protein initiating bone differentiation, J. Biol. Chem., 264, 13377, 1989.","DOI":"10.1016\/S0021-9258(18)80003-5"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.6.2212"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1038\/278855a0"},{"key":"atypb13","doi-asserted-by":"crossref","unstructured":"Weiss, R.E. and Reddi, A.H., Appearance of fibronectin during the differentiation of cartilage, bone and bone marrow, J. Cell Biol., 88, 630, 1980.","DOI":"10.1083\/jcb.88.3.630"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(81)90316-5"},{"key":"atypb15","unstructured":"Reddi, A.H., Regulation of local differentiation of cartilage and bone by extracellular matrix: a cascade type mechanism, in Limb Development and Regeneration, Kelly, R. 0., Goetinck, P. F., and Mac-Cabe, J. A., Eds., Alan R. Liss, New York, 1982, 261."},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.12.7599"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.21.6591"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1210\/mend-5-1-149"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.22.8793"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)90873-L"},{"key":"atypb21","doi-asserted-by":"crossref","unstructured":"Heine, U.I., Munoz, E.F., Flanders, K.C., Ellingsworth, L.R., Sporn, M.B., and Roberts, A.B., Role of transforming growth factor-\u03b2 in the development of the mouse embryo, J. Cell Biol., 105, 2861, 1989.","DOI":"10.1083\/jcb.105.6.2861"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1126\/science.3422517"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.8.2267"},{"key":"atypb24","doi-asserted-by":"crossref","unstructured":"Seyedin, S.M., Thompson, A.Y., Bentz, H., Rosen, D.M., McPherson, J.M., Conti, A., Siegel, N.R., Galluppi, G.R., and Piez, K.A., Cartilage-inducing factor-A, J. Biol. Chem., 261, 5693, 1986.","DOI":"10.1016\/S0021-9258(17)38436-3"},{"key":"atypb25","doi-asserted-by":"crossref","unstructured":"Seyedin, S.M., Segarini, P.R., Rosen, D.M., Thompson, A.Y., Bentz, H., and Graycar, J., Cartilage-inducing factor-\u03b2 is an unique protein structurally and functionally related to transforming growth factor-\u03b2, J. Biol. Chem., 262, 1946, 1987.","DOI":"10.1016\/S0021-9258(18)61601-1"},{"key":"atypb26","doi-asserted-by":"crossref","unstructured":"Sporn, M.B. and Roberts, A.B., The transforming growth factor-\u03b2 s, in Peptide Growth Factors and their Receptors, Sporn, M. B. and Roberts, A. B., Eds., Springer-Verlag, Berlin, 1990, 419.","DOI":"10.1007\/978-3-642-49295-2_8"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1038\/318659a0"},{"key":"atypb28","doi-asserted-by":"crossref","unstructured":"Schwall, R.H., Nikolic, K., Szonyi, E., Gorman, C., and Mason, A.J., Recombinant expression and characterization of human activin A, Mol. Endocrinol., 3, 1237, 1988.","DOI":"10.1210\/mend-2-12-1237"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90783-X"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1038\/325081a0"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90109-7"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.12.4554"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.6.2220"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.11.1657"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.3109\/03008208909023902"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90068-T"},{"key":"atypb37","doi-asserted-by":"crossref","unstructured":"Lyons, K.M., Pelton, R.W., and Hogan, B.L.M., Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A), Development, 109, 833, 1990.","DOI":"10.1242\/dev.109.4.833"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb17979.x"},{"key":"atypb39","doi-asserted-by":"crossref","unstructured":"Carrington, J.L., Roberts, A.B., Flanders, K.C., Roche, N.S., and Reddi, A.H., Accumulation, localization, and compartmentation of transforming growth factor \u03b2 during endochondral bone development, J. Cell Biol., 107, 1969, 1988.","DOI":"10.1083\/jcb.107.5.1969"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(80)90149-9"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90447-4"},{"key":"atypb42","doi-asserted-by":"crossref","unstructured":"Trueta, J., The role of the vessels in osteogenesis, J. Bone J. Surg., 45B, 402, 1963.","DOI":"10.1302\/0301-620X.45B2.402"},{"key":"atypb43","unstructured":"Simmons, D.J., Fracture healing, in Fundamental and Clinical Bone Physiology, Urist, M. R., Ed., Lippincott, Philadelphia, 1980, 283."},{"key":"atypb44","doi-asserted-by":"crossref","unstructured":"Paralkar, V.M., Nandedkar, A.K.N., Pointer, R.H., Kleinman, H.K., and Reddi, A.H., Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen, J. Biol. Chem., 1990, in press.","DOI":"10.1016\/S0021-9258(17)44900-3"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90081-D"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90176-F"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(69)80016-0"},{"key":"atypb48","doi-asserted-by":"crossref","unstructured":"Ripamonti, U., Bone induction in nonhuman primates. An experimental study on the baboon (Papio ursinus), Clin. Orthop. Rel. Res., 269, 284, 1991.","DOI":"10.1097\/00003086-199108000-00039"},{"key":"atypb49","unstructured":"Ripamonti, U., Calvarial reconstruction in primates with porous hydroxyapatite replicas, Plast. Reconstr. Surg., in press."},{"key":"atypb50","doi-asserted-by":"crossref","unstructured":"Schmitz, J.P. and Hollinger, J.O., The critical size defect as an experimental model for craniomandibulofacial nonunions, Clin. Orthop. Rel. Res., 205, 1986.","DOI":"10.1097\/00003086-198604000-00036"},{"key":"atypb51","unstructured":"Ripamonti, U., Ma, S., and Reddi, A.H., Partial purification and biological activity of baboon osteogenin, J. Bone Miner. Res., 4 (Suppl. 1), 409, 1168, 1989."},{"key":"atypb52","unstructured":"Ripamonti, U., Ma, S., Cunningham, N.S., and Reddi, A.H., Initiation of endochondral bone formation and regeneration of calvarial defects in primates by osteogenin, Matrix, submitted."},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820040309"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1126\/science.176.4037.922"},{"key":"atypb55","unstructured":"Weber, J.N. and White, E.W., Carbonate minerals as precursors of new ceramics, metal and polymer materials for biomedical applications, Miner. Sci. Eng., 5, 151, 1973."},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1038\/247220a0"},{"key":"atypb57","doi-asserted-by":"crossref","unstructured":"Chiroff, R.T., White, E.W., Weber, J.N., and Roy, D.M., Tissue ingrowth of replamineform implants, J. Biomed. Mater. Res. Symp., 6, 29, 1975.","DOI":"10.1002\/jbm.820090407"},{"key":"atypb58","doi-asserted-by":"crossref","unstructured":"White, E.W., Weber, J.N., Roy, D.M., and Owen, E.L., Replamineform porous biomaterials for hard tissue implant applications, J. Biomed. Mater. Res. Symp., 6, 23, 1975.","DOI":"10.1002\/jbm.820090406"},{"key":"atypb59","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197905000-00004"},{"key":"atypb60","doi-asserted-by":"crossref","unstructured":"Ripamonti, U., The morphogenesis of bone in porous hydroxyapatite replicas of calcium carbonate coral exoskeletons, J. Bone J. Surg., 1990, submitted.","DOI":"10.2106\/00004623-199173050-00007"},{"key":"atypb61","unstructured":"Ripamonti, U., Ma, S., and Reddi, A.H., Induction of bone in composites of osteogenin and porous hydroxyapatite in baboons, Plast. Reconstr. Surg., in press."},{"key":"atypb62","unstructured":"Ripamonti, U., Inductive bone matrix and porous hydroxyapatite composites in rodents and nonhuman primates, in Handbook of Bioactive Ceramics, Vol. 2, Calcium Phosphate and Hydroxylapatite Ceramics, Yamamuro, T., Wilson-Hench, J., and Hench, L. L., Eds., CRC Press, Boca Raton, FL, 1990, 245."},{"key":"atypb63","doi-asserted-by":"crossref","unstructured":"Glowaki, J., Kaban, L.B., Murray, J.E., Folkman, J., and Mulliken, J.B., Application of the biological principle of induced osteogenesis for craniofacial defects, Lancet, 1, 959, 1981.","DOI":"10.1016\/S0140-6736(81)91730-X"},{"key":"atypb64","doi-asserted-by":"publisher","DOI":"10.1177\/08959374890030010601"},{"key":"atypb65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00901.x"},{"key":"atypb66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1985.tb00426.x"},{"key":"atypb67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01467.x"},{"key":"atypb68","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.10.667"},{"key":"atypb69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb01543.x"},{"key":"atypb70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1987.tb01592.x"},{"key":"atypb71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1989.tb00879.x"},{"key":"atypb72","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.6.371"},{"key":"atypb73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1978.tb00164.x"},{"key":"atypb74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1980.tb00285.x"},{"key":"atypb75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb01391.x"},{"key":"atypb76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb02334.x"},{"key":"atypb77","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555836"},{"key":"atypb78","doi-asserted-by":"crossref","unstructured":"Narang, R. and Wells, H., Bone induction in experimental periodontal bony defects in dogs with decalcified allogeneic bone matrix grafts, Oral Surg., 33, 306, 1990.","DOI":"10.1016\/0030-4220(72)90401-X"},{"key":"atypb79","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1975.46.1.51"},{"key":"atypb80","unstructured":"Sonis, S.T., Kaban, S.T., and Glowaki, J., Clinical trial of demineralized bone powder in the treatment of periodontal defects, J. Oral Med., 38, 117, 1983."},{"key":"atypb81","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.7.381"},{"key":"atypb82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1985.tb00453.x"},{"key":"atypb83","unstructured":"Ripamonti, U., Ma, S., and Reddi, A.H., unpublished data."}],"container-title":["Critical Reviews in Oral Biology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10454411920030010101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10454411920030010101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T16:19:59Z","timestamp":1727626799000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10454411920030010101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1177\/10454411920030010101"],"URL":"https:\/\/doi.org\/10.1177\/10454411920030010101","relation":{},"ISSN":["1045-4411","1544-1113"],"issn-type":[{"value":"1045-4411","type":"print"},{"value":"1544-1113","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}