{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T04:19:31Z","timestamp":1727669971951},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Reviews in Oral Biology &amp; Medicine"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:p> At birth, the rat submandibular gland (SMG) contains two transient secretory cell types that produce several characteristic salivary proteins. Proteins SMG-A, B1, and B2 (23.5, 26 and 27.5 kDa) are products of the neonatal type III cells, but not the adult acinar cells. Protein C (89 kDa), a major product of the neonatal type I cells, is either absent or present at greatly diminished levels in the secretory cells of the adult gland. The decrease in biosynthesis of these neonatal salivary proteins occurs concomitantly with the increase in levels of characteristic adult SMG products. In order to understand these developmentally regulated changes in SMG salivary protein gene expression, we have initiated the molecular cloning and characterization of neonatal submandibular gland proteins from a 5-d-old rat submandibular gland cDNA library. Clones encoding SMG-A were isolated by homology to the mouse parotid secretory protein (PSP). SMG-A was shown to be derived from a salivary protein multigene family that also includes PSP. Cloning and characterization of additional neonatal rat submandibular gland proteins was initiated by screening the 5-d-old rat submandibular gland cDNA library with first strand cDNA prepared from 1-d-old rat submandibular glands. Clones corresponding to a highly abundant 3 kb transcript present in the neonatal rat SMG, but not in adult submandibular, sublingual, or parotid gland have been identified. The size, abundance, and organ specificity of this transcript suggest that it may encode protein C. One clone derived from an unknown transcript that is developmentally regulated in the neonatal SMG and is present in the adult parotid, submandibular, and sublingual glands was also identified. <\/jats:p>","DOI":"10.1177\/10454411930040033801","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:46:03Z","timestamp":1483663563000},"page":"525-530","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Cloning of Developmentally Regulated Neonatal Rat Submandibular Gland Proteins"],"prefix":"10.1177","volume":"4","author":[{"given":"Lily","family":"Mirels","sequence":"first","affiliation":[{"name":"Biology Department University of California, San Diego, 2425 Bonner Hall, 9500 Gilman Dr., La Jolla, CA 92093-0322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa R.","family":"Girard","sequence":"additional","affiliation":[{"name":"Biology Department University of California, San Diego, 2425 Bonner Hall, 9500 Gilman Dr., La Jolla, CA 92093-0322"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Anatomy and the Howard University Cancer Center Howard University College of Medicine, Washington, D.C. 20059"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1978.tb00957.x"},{"key":"atypb2","unstructured":"Ball, W.D. and R.S. Redman: Two Independently Regulated Secretory Systems within the Acini of the Submandibular Gland of the Perinatal Rat. Eur. J. Cell Biol. 33:112-122 (1984)."},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90210-2"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90393-4"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091780204"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90280-2"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215847"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02603120"},{"key":"atypb9","doi-asserted-by":"crossref","unstructured":"Heinrich, G. and J.F. Habener: Genes Encoding Proteins with Homologous Contiguous Repeat Sequences are Highly Expressed in the Serous Cells of the Rat Submandibular Gland. J. Biol. Chem. 262:5262-5270 (1987).","DOI":"10.1016\/S0021-9258(18)61183-4"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(84)90058-X"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(75)90162-2"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/13.1.1"},{"key":"atypb13","doi-asserted-by":"crossref","unstructured":"Mirels, L., G.S. Bedi, D.P. Dickinson, M. Dziejman, and L.A. Tabak: Molecular Characterization of Glutamic Acid\/ Glutamine-Rich Secretory Proteins from Rat Submandibular Glands. J. Biol. Chem. 262:7289-7297 (1987).","DOI":"10.1016\/S0021-9258(18)48235-X"},{"key":"atypb14","unstructured":"Mirels, L. and W.D. Ball: Rat Salivary Protein SMG-A is Homologous to Mouse PSP. J. Dent. Res. 69(Spec. Iss):121 (abstract #103) (1990)."},{"key":"atypb15","doi-asserted-by":"crossref","unstructured":"Mirels, L. and W.D. Ball: Neonatal Rat Submandibular Gland Protein SMG-A and Parotid Secretory Protein are Alternatively Regulated Members of a Salivary Protein Multigene Family. J. Biol. Chem. in press (1992).","DOI":"10.1016\/S0021-9258(18)45934-0"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90306-4"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001910204"},{"key":"atypb18","doi-asserted-by":"crossref","unstructured":"Owerbach, D. and J.P. Hjorth: Inheritance of a Parotid Secretory Protein in Mice and Its Use in Determining Salivary Amylase Quantitative Variants. Genetics 95:129-141 (1980).","DOI":"10.1093\/genetics\/95.1.129"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(69)90270-2"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(84)90168-9"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(86)90277-9"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90371-5"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(85)90222-X"},{"key":"atypb24","doi-asserted-by":"crossref","unstructured":"Yamashina, S. and T. Barka: Localization of Peroxidase Activity in the Developing Submandibular Gland of Normal and Isoproterenol-Treated Rats. J. Histochem. 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