{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T02:10:04Z","timestamp":1749867004764,"version":"3.41.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Critical Reviews in Oral Biology &amp; Medicine"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>The salivary glands of rodents undergo considerable cytodifferentiation after birth and are useful models for the study of functional development, including the mechanisms of fluid and electrolyte secretion. In the rat submandibular gland, secretion of salivary fluid cannot be elicited until approximately 2 weeks of age. The currently accepted model of salivary fluid secretion indicates that this process depends on the activation, on stimulation of cholinergic receptors, of several ion transport systems, resulting in a net transport of osmotically active ions (primarily Cl<jats:sup>-<\/jats:sup>and Na<jats:sup>+<\/jats:sup>) across the acinar epithelium. This creates the necessary osmotic gradient for the transacinar movement of water. The process is associated with a signal transduction pathway involving the formation of phosphoinositide products (primarily inositol triphosphate or IP3) and the mobilization of Ca2+. The latter regulates monovalent ion conductances (K+, CI-), which are critical for the secretory process. Immature submandibular glands and cells of early postnatal rats have a lower density of cholinergic receptors and release less K+ and Cl<jats:sup>-<\/jats:sup>than mature cells and gradually develop other ion transport systems (such as a Na, K, 2Cl cotransport system) involved in the secretory process. Surprisingly, they form more IP3 and show a larger increase in cytosolic Ca2+ when stimulated with maximal or supramaximal concentrations of agonist. Therefore, they show some interesting dissociations in the signal transduction mechanism that suggest differences in the coupling between receptors and membrane phosphoinositides, between IP3 and IP<jats:sub>3<\/jats:sub>-dependent Ca2+ stores, and between the Ca2+ signal and the monovalent ion transport systems which are critical for secretion.<\/jats:p>","DOI":"10.1177\/10454411940050030401","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:25:16Z","timestamp":1483662316000},"page":"281-290","source":"Crossref","is-referenced-by-count":10,"title":["Developmental Aspects of Fluid and Electrolyte Secretion in Salivary Glands"],"prefix":"10.1177","volume":"5","author":[{"given":"J. Ricardo","family":"Martinez","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center, Department of Pediatrics, 7703 Floyd Curl Drive, San Antonio, TX 78284-7827"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90305-4"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(74)90056-3"},{"key":"atypb3","doi-asserted-by":"crossref","unstructured":"Batzri, S., Z. Selinger, M. Schramm, and M.R. Robinovitch: Potassium Release Mediated by the Epinephrine a Receptor in Rat Parotid Slices. J. Biol. Chem. 248:361 (1973).","DOI":"10.1016\/S0021-9258(19)44482-7"},{"key":"atypb4","doi-asserted-by":"crossref","unstructured":"Baum, B.J.: Neurotransmitter Control of Secretion. J. Dent. Res. 66:628 (1986).","DOI":"10.1177\/00220345870660S104"},{"key":"atypb5","unstructured":"Baum, B.J., I.S. Ambudkar, and V.J. Horn: Neurotransmitter Control of Calcium Mobilization. In: Biology of the Salivary Glands, pp. 153. (K. Dobrosielski-Vergona, Ed.) CRC Press, Boca Raton, FL (1993)."},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1177\/10454411930040031701"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/361315a0"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(82)90100-5"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02143588"},{"key":"atypb10","doi-asserted-by":"crossref","unstructured":"Cutler, L.S. and A.P. Chaudhry: Intercellular Contacts at the Epithelial-Mesenchymal Interface during the Prenatal Development of the Rat Submandibular Gland. J. Morph. 33:229 (1973).","DOI":"10.1016\/0012-1606(73)90133-4"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90280-2"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001430204"},{"key":"atypb13","doi-asserted-by":"crossref","unstructured":"Cutler, L.S. and S.B. Rodan: Biochemical and Cytochemical Studies on Adenylate Cyclase in the Developing Rat Submandibular Gland: Differentiation of the Acinar Secretory Compartment. J. Embryo. Exp. Morph. 36:291 (1976).","DOI":"10.1242\/dev.36.2.291"},{"key":"atypb14","doi-asserted-by":"crossref","unstructured":"Cutler, L.S., C.P. Christian, and B. Boltaro: Development of Stimulus-Secretion Coupling in Salivary Glands. In: Methods of Cell Biology, pp. 23-551. (A. R. Hand and C. Oliver, Eds.) Academic Press, New York (1981).","DOI":"10.1016\/S0091-679X(08)61518-6"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660S207"},{"key":"atypb16","doi-asserted-by":"crossref","unstructured":"Fava de Moraes, F. and J. Nicolau: Aging Effects on Sialic Acid Concentration of Submandibular-Sublingual Glands of Rats. Naturwissenschaften 53:711 (1966).","DOI":"10.1007\/BF00602745"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.4.1461"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1975.228.2.608"},{"key":"atypb19","doi-asserted-by":"crossref","unstructured":"Grand, R.J. and M.I. Schay: Development of Secretory Function in Rat Parotid Gland. Pediat. Rev. 12:100 (1978).","DOI":"10.1203\/00006450-197802000-00007"},{"key":"atypb20","unstructured":"Holzgreve, H., J.R. Martinez, and A. Vogel: Micropuncture and Histologic Study of Submaxillary Glands of Young Rats. Pflugers Arch. 290:1134 (1968)."},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1042\/bj2040673"},{"key":"atypb22","unstructured":"Jacoby, F. and C.R. Leeson: The Postnatal Development of the Rat Submaxillary Gland. J. Anat. 93:201 (1966)."},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091680402"},{"key":"atypb24","unstructured":"Leeson, C.R. and F. Jacoby: An Electron Microscopic Study of the Rat Submaxillary Gland during Its Postnatal Development and in the Adult. J. Anat. ( London) 93:287 (1959)."},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1007\/BF00362655"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1007\/BF00363690"},{"key":"atypb27","doi-asserted-by":"crossref","unstructured":"Martinez, J.R. and D.O. Quissell: Potassium Release from the Rat Submaxillary Gland In Vitro. II. Induction by Parasympathomimetic Secretagogues. J. Pharmacol. Exp. Ther. 199:518 (1976).","DOI":"10.1016\/S0022-3565(25)30713-5"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(82)90100-5"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1177\/00220345830620050501"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(83)90166-8"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1007\/BF01940707"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(86)90046-4"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582641"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(87)90041-0"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(88)90046-5"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(89)90001-0"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660S206"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1177\/10454411900010010601"},{"key":"atypb39","doi-asserted-by":"crossref","unstructured":"Marty, A.: Calcium Release and Internal Calcium Regulation in Acinar Cells of Exocrine Glands. J. Membr. Biol. 1124:189 (1991).","DOI":"10.1007\/BF01994353"},{"key":"atypb40","doi-asserted-by":"crossref","unstructured":"Petersen, O.H.: Calcium-Activated Potassium Channels and Fluid Secretion by Exocrine Glands. Am. J. Physiol. 251:61 (1986).","DOI":"10.1152\/ajpgi.1986.251.1.G1"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.54.030192.001211"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.48.030186.000451"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.46.1.81"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1961.201.5.939"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1972.223.1.172"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91353-R"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-203-43628"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001040106"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1042\/bj2580409"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90505-9"},{"key":"atypb51","doi-asserted-by":"publisher","DOI":"10.1007\/BF00588449"},{"key":"atypb52","unstructured":"Young, J.A. and E.W. van Lennep: The Morphology of Salivary Glands, Academic Press, London (1978)."},{"key":"atypb53","doi-asserted-by":"crossref","unstructured":"Young, J.A. and E.W. van Lennep: Transport in Salivary and Salt Glands. In: Membrane Transport in Biology, pp. 563. (G. Giebish, D. C. Tosteson, and H. H. Ussing, Eds.) Springer-Verlag, Heidelberg (1979).","DOI":"10.1007\/978-3-642-81256-9_3"},{"key":"atypb54","unstructured":"Young, J.A.: Salivary Secretion of Inorganic Electrolytes. Int. Rev. Physiol. 19:1 (1979)."},{"key":"atypb55","unstructured":"Young, J.A. and D.I. Cook: Secretion of Salt and Water by Glandular Epithelia. Biomed. Res. 7(Suppl. 2):165 (1985)."}],"container-title":["Critical Reviews in Oral Biology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10454411940050030401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10454411940050030401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T01:46:54Z","timestamp":1749865614000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10454411940050030401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1177\/10454411940050030401"],"URL":"https:\/\/doi.org\/10.1177\/10454411940050030401","relation":{},"ISSN":["1045-4411","1544-1113"],"issn-type":[{"type":"print","value":"1045-4411"},{"type":"electronic","value":"1544-1113"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}