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With the establishment of national and international marrow banks, unrelated allogeneic BMT is being performed with increasing frequency. Graft-vs.-host disease (GVHD) remains a major complication of allogeneic BMT, occurring in 25% to 70% of patients despite GVHD prophylaxis, with the skin, gastro-intestinal tract, and liver as primary target organs. Oral findings are seen in both acute and chronic GVHD. In acute GVHD, the oral lesions are often painful, erythematous, ulcerative, and desquamative. In chronic GVHD, they are lichenoid with associated erythema and ulcerations; additionally, they may be associated with a sicca syndrome characterized by xerostomia and progressive salivary gland atrophy. General principles of BMT are discussed, as are systemic and local therapeutic options for oral GVHD. <\/jats:p>","DOI":"10.1177\/10454411970080020701","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:40:32Z","timestamp":1231461632000},"page":"201-216","source":"Crossref","is-referenced-by-count":106,"title":["Graft-vs.-Host Disease"],"prefix":"10.1177","volume":"8","author":[{"given":"Sook-Bin","family":"Woo","sequence":"first","affiliation":[{"name":"Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Joi","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Brigham and Women's Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Schubert","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, Fred Hutchinson Cancer Research (enter, Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199312000-00045"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90231-R"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199211000-00015"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.12.2964.2964"},{"key":"atypb5","unstructured":"Antin JH, Smith BR (1995). 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