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The President\u2019s Council of Economic Advisers estimates that more than 1 million workers are out of the workforce due to the opioid crisis. The impact on workers is equally profound, including job loss, divorce and family disruption, and potentially imprisonment, injury, illness, and death. Pain from occupational injuries and illnesses and stress are important pathways to opioid use disorder. Effective workplace programs that incorporate the public health approach to prevention offer a significant opportunity to prevent and respond to the opioid crisis. To date, the nation\u2019s efforts at combating the crisis have not included the necessary policy reforms to transform the workplace from a pathway to opioid misuse to a pathway to prevention, including education of workers, unions, employers, and health care providers and treatment and recovery of affected workers. Several key policy interventions are recommended to address this disconnect, including prevention of workplace injury, illness, and emotional distress; worker education and training; and replacement of stigmatizing, punitive workplace substance use programs with supportive programs. Increasing access to alternative pain treatment and preventing opioid misuse in workers\u2019 compensation systems are other key policy recommendations.<\/jats:p>","DOI":"10.1177\/10482911211031012","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T12:57:55Z","timestamp":1625576275000},"page":"373-383","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Public Health Approach to Protecting Workers from Opioid Use Disorder and Overdose Related to Occupational Exposure, Injury, and Stress"],"prefix":"10.1177","volume":"31","member":"179","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"bibr1-10482911211031012","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6911a4"},{"key":"bibr2-10482911211031012","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.16932"},{"key":"bibr3-10482911211031012","unstructured":"Xu JQ, Murphy SL, Kochanek KD, Arias E. 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