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We recruited 25 men in British Columbia who received an acute ( n = 13) or recent ( n = 12) HIV diagnosis to engage in a longitudinal multiple-methods study over one year or longer. Our thematic analysis of baseline qualitative interviews revealed insights within men\u2019s accounts of technologically mediated processes of HIV discovery and diagnosis. Our analysis illuminated the dialectic of new HIV technologies in practice by considering the relationship between advances in diagnostics (e.g., nucleic acid amplification tests) and the users of these medical technologies in clinical settings (e.g., clients and practitioners). Technological innovations and testing protocols have shifted experiences of learning of one\u2019s HIV-positive status; these innovations have created new diagnostic categories that require successful interpretation and translation to be rendered meaningful, to alleviate uncertainty, and to support public health objectives.<\/jats:p>","DOI":"10.1177\/1049732314549813","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:02:25Z","timestamp":1410220945000},"page":"205-217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic Technologies in Practice"],"prefix":"10.1177","volume":"25","author":[{"given":"Daniel","family":"Grace","sequence":"first","affiliation":[{"name":"London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Simon Fraser University, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kwag","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Chown","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Doupe","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Trussler","sequence":"additional","affiliation":[{"name":"Community Based Research Centre for Gay Men\u2019s Health, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rekart","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gilbert","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,9,8]]},"reference":[{"key":"bibr1-1049732314549813","doi-asserted-by":"publisher","DOI":"10.7748\/nr2011.04.18.3.6.c8457"},{"key":"bibr2-1049732314549813","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir793"},{"key":"bibr3-1049732314549813","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"bibr4-1049732314549813","doi-asserted-by":"publisher","DOI":"10.1086\/512088"},{"key":"bibr5-1049732314549813","unstructured":"British Columbia Centre for Disease Control. 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