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The design of culturally sensitive HCV treatment programs is lacking. The objective was to employ community-based participatory research methods to understand perceptions of HCV-positive PEH, and providers, on the design and delivery of a culturally sensitive, nurse-led community health worker (RN\/CHW) HCV initiation and completion program. Four focus group sessions were conducted with HCV-positive PEH ( n = 30) as well as homeless service providers (HSP; n = 7) in Skid Row, Los Angeles. An iterative, thematic approach provided the themes of essentials of successful participant engagement and retention: Role of nurse-Led CHW in promoting: (a) tangible and emotional support; (b) cognitive and behavioral support; and (c) financial and structural resources. The goal of this study is to provide the groundwork for future research of HCV program design to support HCV cure among homeless populations.<\/jats:p>","DOI":"10.1177\/10497323211021782","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T08:02:47Z","timestamp":1625040167000},"page":"2069-2083","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Engaging the Community in Designing a Hepatitis C Virus Treatment Program for Adults Experiencing Homelessness"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-6620","authenticated-orcid":false,"given":"Adeline M.","family":"Nyamathi","sequence":"first","affiliation":[{"name":"University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Akure","family":"Wall","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartik","family":"Yadav","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghyuk S.","family":"Shin","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Chang","sequence":"additional","affiliation":[{"name":"Los Angeles County Department of Public Health, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Arce","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Cuellar","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Irvine, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Fernando","sequence":"additional","affiliation":[{"name":"Los Angeles Christian Health Centers, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"White","sequence":"additional","affiliation":[{"name":"Los Angeles Christian Health Centers, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Gelberg","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine at UCLA, Los Angeles, California, USA"},{"name":"VA Greater Los Angeles Healthcare System, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benissa E.","family":"Salem","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"bibr1-10497323211021782","unstructured":"AbbVie. 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