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Semi-structured interviews were conducted with live kidney donors who donated through University of Louisville Health, Trager Transplant Center, a mid-scale transplant program, in the years 2017 through 2019. The interview transcripts were analyzed for barriers and facilitators to live kidney donation within a sociotechnical system. The most salient facilitators included: having an informative, caring, and available care team; the absence of any negative external pressure toward donating; donating to a family or friend; and the ability to take extra time off work for recovery. The most recurrent barriers included: short\/medium-term (&lt;1\u00a0year) negative health impacts because of donation; the need to make minor lifestyle changes (e.g., less alcohol consumption) after donation; and mental health deterioration stemming from the donation process. The sociotechnical systems framework promotes a balanced system comprised of social, technical, and environmental subsystems. Assessing the facilitators and barriers from the sociotechnical system perspective revealed the importance of and opportunities for developing strategies to promote integration of technical subsystem, such as social media apps and interactive AI platforms, with social and environmental subsystems to enable facilitators and reduce barriers effectively.<\/jats:p>","DOI":"10.1177\/10497323231224706","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:58:10Z","timestamp":1705453090000},"page":"691-702","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Understanding Barriers and Facilitators to Living Kidney Donation Within a Sociotechnical Systems Framework"],"prefix":"10.1177","volume":"34","author":[{"given":"Rachel","family":"Crenshaw","sequence":"first","affiliation":[{"name":"Department of Industrial Engineering, University of Louisville, Louisville, KY, USA"},{"name":"Analytics, Planning, Strategy and Improvement, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cary","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering, University of Louisville, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoru","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Schar School of Policy and Government, George Mason University, Fairfax, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitarth S.","family":"Dave","sequence":"additional","affiliation":[{"name":"Division of Nephrology & Hypertension, School of Medicine, University of Louisville, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gentili","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering, University of Louisville, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-5170","authenticated-orcid":false,"given":"Jason J.","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering, University of Louisville, Louisville, KY, USA"},{"name":"Center for Human Systems Engineering, University of Louisville, Louisville, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"bibr1-10497323231224706","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2013.10.007"},{"key":"bibr2-10497323231224706","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-5056(07)00078-0"},{"key":"bibr3-10497323231224706","doi-asserted-by":"publisher","DOI":"10.2196\/37884"},{"key":"bibr4-10497323231224706","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2006.05.017"},{"key":"bibr5-10497323231224706","doi-asserted-by":"publisher","DOI":"10.1111\/jorc.12267"},{"key":"bibr6-10497323231224706","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq388"},{"key":"bibr7-10497323231224706","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-5056(99)00011-8"},{"key":"bibr8-10497323231224706","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.2194"},{"key":"bibr9-10497323231224706","doi-asserted-by":"publisher","DOI":"10.1197\/jamia.M2384"},{"key":"bibr23-10497323231224706","volume-title":"Organ Procurement & Transplantation Network (OPTN)","author":"Health Resources &amp; Services Administration (HRSA)"},{"key":"bibr10-10497323231224706","volume-title":"Macroergonomics: An introduction to work system design","author":"Hendrick H. 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