{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:38:46Z","timestamp":1777383526967,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,8,21]],"date-time":"2009-08-21T00:00:00Z","timestamp":1250812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>Diphenhydramine is an antihistamine with anticholinergic properties, which has been used for the treatment of Parkinson disease (PD) prior to the development of newer agents with better side-effect profiles. However, most of these agents are given orally. Unfortunately, at the time of death, patients with paralysis agitans are no longer able to swallow and they can experience worsening of their tremors. We report the case of 1 patient with congestive heart failure (CHF) and PD who was unable to swallow and developed uncontrollable tremors 24 hours prior to death and whose tremors were successfully treated with diphenhydramine. We feel that in preimminent patients who cannot swallow or may not have perioral endoscopic gastrostomy (PEG)s or feeding tubes, parenteral diphenhydramine may be an appropriate palliative intervention to reduce tremors.<\/jats:p>","DOI":"10.1177\/1049909109338937","type":"journal-article","created":{"date-parts":[[2009,8,21]],"date-time":"2009-08-21T21:42:18Z","timestamp":1250890938000},"page":"474-475","source":"Crossref","is-referenced-by-count":13,"title":["Diphenhydramine May Be Useful as a Palliative Treatment for Patients Dying With Parkinson\u2019s Disease and Tremors: A Case Report and Discussion"],"prefix":"10.1177","volume":"26","author":[{"given":"Faustino","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Access at Hospice of Palm Beach County, West Palm Beach, Department of Internal Medicine, Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, Florida,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,8,21]]},"reference":[{"key":"atypb1","unstructured":"Bianchine JR Drugs for Parkinson\u2019s disease, spasticity, and acute muscle spasms. In: Goodman Gilman A, Goodman LS, Rall TW, Murad F, eds. Goodman and Gillman\u2019s The Pharmacological Basis of Therapeutics. 7th ed. New York, NY: McGraw-Hill; 1985:483-485."},{"issue":"2","key":"atypb2","first-page":"39","volume":"2","author":"Brocks DR","year":"1999","journal-title":"J Pharm Pharmaceut Sci"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef268"},{"issue":"2","key":"atypb4","first-page":"144","volume":"22","author":"Scotti G.","year":"1970","journal-title":"Sist Nerv"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(94)90045-0"},{"issue":"5","key":"atypb6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1345\/aph.19213","volume":"34","author":"Elliott ES","year":"2000","journal-title":"Ann Pharmacother"},{"issue":"4","key":"atypb7","first-page":"293","volume":"5","author":"Demetropoulos S.","year":"1987","journal-title":"\u2019\u2019 Ann Emerg Med"},{"key":"atypb8","first-page":"CD003735","volume":"2","author":"Katzenschlager R.","year":"2003","journal-title":"Cochrane Database Syst Rev"}],"container-title":["American Journal of Hospice and Palliative Medicine\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909109338937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909109338937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:26:37Z","timestamp":1777368397000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1049909109338937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,21]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1177\/1049909109338937"],"URL":"https:\/\/doi.org\/10.1177\/1049909109338937","relation":{},"ISSN":["1049-9091","1938-2715"],"issn-type":[{"value":"1049-9091","type":"print"},{"value":"1938-2715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,21]]}}}