{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:40:03Z","timestamp":1777383603906,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>Refractory cancer pain may be effectively controlled by titrating intracerebroventricular (ICV) preservative-free opioid. In this case report, a continuous infusion of ICV morphine permitted our patient with lung cancer and painful spinal metastases to be discharged to home hospice with family. The approach exploits the high potency of morphine injected into cerebrospinal fluid (CSF). Sterile, injectable, preservative-free morphine is directly infused into CSF through a subcutaneous Ommaya reservoir placed under the scalp by a neurosurgeon, with an attached catheter passed through a burr hole in the skull with its tip in a cerebral ventricle. Although investigators have described home care of patients receiving intraspinal analgesics, no report describes the process of transitioning the patient receiving continuous ICV morphine infusion to the home setting.<\/jats:p>","DOI":"10.1177\/1049909109355150","type":"journal-article","created":{"date-parts":[[2010,1,27]],"date-time":"2010-01-27T00:18:42Z","timestamp":1264551522000},"page":"326-332","source":"Crossref","is-referenced-by-count":8,"title":["Intracerebroventricular Morphine for Refractory Cancer Pain: Transitioning to the Home Setting"],"prefix":"10.1177","volume":"27","author":[{"given":"Michael D.","family":"Adolph","sequence":"first","affiliation":[{"name":"Medicine and Surgery, James Cancer Hospital and Solove Research Institute, Ohio State University Medical Center, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Stretanski","sequence":"additional","affiliation":[{"name":"MedCentral Hospice; Interventional Spine & Pain Rehabilitation Center, Ltd, Mansfield, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"McGregor","sequence":"additional","affiliation":[{"name":"Neurological Surgery, Ohio State University Medical Center, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie L.","family":"Rawn","sequence":"additional","affiliation":[{"name":"James Cancer Hospital and Solove Research Institute, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Thoracic Surgery, Ohio State University Medical Center, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, James Cancer Hospital and Solove Research Institute, Ohio State University Medical Center, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","unstructured":"Benedetti C., Ibinson J., Adolph MD Cancer pain: anesthetic and neurosurgical interventions. In: Declan Walsh, ed. Palliative Medicine. New York, NY: Elsevier; 2008:18-22.","DOI":"10.1016\/B978-0-323-05674-8.50251-6"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1987.tb02672.x"},{"issue":"1","key":"atypb3","first-page":"CD005178","author":"Ballantyne JC","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1983.59.4.0627"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.89.203"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2000.3.287"},{"issue":"10","key":"atypb7","first-page":"455","volume":"34","author":"Ommaya AK","year":"1965","journal-title":"Med Ann Dist Columbia"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1965.03090200007001"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.56.2.0241"},{"key":"atypb10","volume-title":"PDQ Professional Version","author":"National Cancer Institute.","year":"2008"},{"key":"atypb11","unstructured":"Fisch M., Cleeland CS Managing cancer pain. In: Skeel R., ed. Handbook of cancer chemotherapy. Philadelphia, PA: Lippincott, Williams, & Wilkins ; 2003:663."},{"key":"atypb12","volume-title":"Integra reservoir product description","author":"Integra.com.","year":"2009"},{"key":"atypb13","unstructured":"Tasker RR Neurostimulation and percutaneous neural destructive techniques. In: Cousins MJ, Bridenbaugh PO , eds. Neural Blockade in Clinical Anesthesia and Management of Pain\/Editors. Philadelphia, PA: Lippincott-Raven; 1998:1063-1134."},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(03)00311-7"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00373-6"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(96)00203-5"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1038\/258577a0"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2515"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200207"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1984.tb02148.x"},{"issue":"2","key":"atypb21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0022-3565(25)20832-1","volume":"251","author":"Paul D.","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198611020-00001"},{"issue":"1","key":"atypb23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1213\/00000539-199901000-00021","volume":"88","author":"Smith MT","year":"1999","journal-title":"Anesth Analg"}],"container-title":["American Journal of Hospice and Palliative Medicine\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909109355150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909109355150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:26:48Z","timestamp":1777368408000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1049909109355150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,26]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1177\/1049909109355150"],"URL":"https:\/\/doi.org\/10.1177\/1049909109355150","relation":{},"ISSN":["1049-9091","1938-2715"],"issn-type":[{"value":"1049-9091","type":"print"},{"value":"1938-2715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,26]]}}}