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All had difficult to control pain, and a third required 5 or more analgesic agents. Two patients had documented \u2018\u2018drug-seeking\u2019\u2019 behavior. Methadone was used subcutaneously as an analgesic agent in 1 patient. We explore why patients on MMT have difficult to manage pain, the optimal management of their pain, and the increasing role of methadone as an analgesic agent in cancer pain.<\/jats:p>","DOI":"10.1177\/1049909110380897","type":"journal-article","created":{"date-parts":[[2010,9,8]],"date-time":"2010-09-08T20:39:42Z","timestamp":1283978382000},"page":"183-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Review of Cancer Pain Management in Patients Receiving Maintenance Methadone Therapy"],"prefix":"10.1177","volume":"28","author":[{"given":"Dominic","family":"Rowley","sequence":"first","affiliation":[{"name":"St Francis Hospice, Raheny, Dublin, Ireland,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Mater Misericordiae Hospital, Eccles St, Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisling","family":"O'Gorman","sequence":"additional","affiliation":[{"name":"St Francis Hospice, Raheny, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Ryan","sequence":"additional","affiliation":[{"name":"St Francis Hospice, Raheny, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"McQuillan","sequence":"additional","affiliation":[{"name":"St Francis Hospice, Raheny, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,9,8]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1080\/10826080902810251"},{"key":"atypb2","volume":"2","author":"Reynolds S.","journal-title":"2008 HRB Trends Series"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/s11013-008-9089-z"},{"key":"atypb4","volume-title":"National Drug Treatment Reporting System-statistical Bulletin 1997 and 1998","author":"O\u2019Brien M."},{"key":"atypb5","author":"Cox G.","year":"2008","journal-title":"A Joint Report by the National Drugs Strategy Team and the National Advisory Committee on Drugs"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(95)00052-Z"},{"key":"atypb7","unstructured":"Pain and substance misuse: improving the patient experience. 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