{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:24:41Z","timestamp":1783790681841,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Morphine is the only opioid which has been clearly demonstrated as effective in the treatment of dyspnea. The role of other opioids has not been sufficiently substantiated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the efficacy of oral transmucosal fentanyl citrate (OTFC) in the treatment of dyspnea on exertion in patients with advanced cancer. Design: This is a randomized, double-blind crossover clinical trial to evaluate the efficacy of OTFC in dyspnea on exertion after the completion of a 6-minute walk test (6MWT). All patients were attended in 2011 by the Palliative Care Supportive Team from Badajoz. In visit 1, patients were randomly assigned to 1 of the 2 treatment groups. In visit 2, the patients who had been receiving the investigational product were given placebos and vice versa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirteen patients were recruited (26 6MWT), with a mean age of 65 years. Of the patients, 11 (76%)were males and lung cancer was the most frequently represented etiology. The patients were classified into 3e categories: better response in the first period, the same response in both the periods, and better response in the second period. No differences between the treatments were demonstrated ( P: 1). There were no differences in changes in oxygen saturation ( P: .7541) nor in the distance walked in the different sequences ( P: .6550). No significant differences were found in relation to the Edmonton Symptom Assessment System, either before or after the 6MWT ( P: .1234). No secondary effects associated with the medication were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It could not be demonstrated that the OTFC improved exertion dyspnea in patients with advanced cancer. A placebo effect was observed in all the patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1049909113513063","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T21:19:58Z","timestamp":1384982398000},"page":"298-304","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["A Randomized Crossover Clinical Trial to Evaluate the Efficacy of Oral Transmucosal Fentanyl Citrate in the Treatment of Dyspnea on Exertion in Patients With Advanced Cancer"],"prefix":"10.1177","volume":"32","author":[{"given":"Miguel \u00c1ngel Cuervo","family":"Pinna","sequence":"first","affiliation":[{"name":"Palliative Care Team of Badajoz, Regional Programme for Palliative Care in Extremadura, Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bruera","sequence":"additional","affiliation":[{"name":"Department of Palliative Care & Rehabilitation Medicine, F.T. McGraw Chair in the Treatment of Cancer Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9 Redondo","family":"Moralo","sequence":"additional","affiliation":[{"name":"Palliative Care Team of Badajoz, Regional Programme for Palliative Care in Extremadura, Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel S\u00e1nchez","family":"Correas","sequence":"additional","affiliation":[{"name":"Palliative Care Team of Badajoz, Regional Programme for Palliative Care in Extremadura, Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Mota","family":"Vargas","sequence":"additional","affiliation":[{"name":"Palliative Care Team of Badajoz, Regional Programme for Palliative Care in Extremadura, Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"bibr1-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.ats898"},{"key":"bibr2-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(00)00126-3"},{"key":"bibr3-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.02.022"},{"key":"bibr4-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1177\/1049909108327588"},{"key":"bibr5-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.11.939"},{"key":"bibr6-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.5796"},{"key":"bibr7-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0389-6"},{"key":"bibr8-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2009.0113"},{"key":"bibr9-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.10.002"},{"key":"bibr10-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2007.0161"},{"key":"bibr11-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1002\/0470854596"},{"key":"bibr12-1049909113513063","doi-asserted-by":"publisher","DOI":"10.2307\/2556170"},{"key":"bibr13-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.01.011"},{"key":"bibr14-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.08.016"},{"key":"bibr15-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.05.007"},{"key":"bibr16-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00391-8"},{"key":"bibr17-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.08.002"},{"key":"bibr18-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0310-3"},{"key":"bibr19-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.08.016"},{"key":"bibr20-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"bibr21-1049909113513063","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00391-8"}],"container-title":["American Journal of Hospice and Palliative Medicine\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909113513063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1049909113513063","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909113513063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:28:57Z","timestamp":1777368537000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1049909113513063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,20]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1177\/1049909113513063"],"URL":"https:\/\/doi.org\/10.1177\/1049909113513063","relation":{},"ISSN":["1049-9091","1938-2715"],"issn-type":[{"value":"1049-9091","type":"print"},{"value":"1938-2715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,20]]}}}