{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:40:57Z","timestamp":1778049657676,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Malignant bowel obstruction is a highly symptomatic, often recurrent, and sometimes refractory condition in patients with intra-abdominal tumor burden. Gastro-intestinal symptoms and function may improve with anti-inflammatory, anti-secretory, and prokinetic\/anti-nausea combination medical therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe the effect of octreotide, metoclopramide, and dexamethasone in combination on symptom burden and bowel function in patients with malignant bowel obstruction and dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A retrospective case series of patients with malignant bowel obstruction (MBO) and malignant bowel dysfunction (MBD) treated by a palliative care consultation service with octreotide, metoclopramide, and dexamethasone. Outcomes measures were nausea, pain, and time to resumption of oral intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>12 cases with MBO, 11 had moderate\/severe nausea on presentation. 100% of these had improvement in nausea by treatment day #1. 100% of patients with moderate\/severe pain improved to tolerable level by treatment day #1. The median time to resumption of oral intake was 2 days (range 1-6 days) in the 8 cases with evaluable data. Of 7 cases with MBD, 6 had For patients with malignant bowel dysfunction, of those with moderate\/severe nausea. 5 of 6 had subjective improvement by day#1. Moderate\/severe pain improved to tolerable levels in 5\/6 by day #1. Of the 4 cases with evaluable data on resumption of PO intake, time to resume PO ranged from 1-4 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Combination medical therapy may provide rapid improvement in symptoms associated with malignant bowel obstruction and dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1049909115569047","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T23:24:58Z","timestamp":1422919498000},"page":"407-410","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Medical Therapy of Malignant Bowel Obstruction With Octreotide, Dexamethasone, and Metoclopramide"],"prefix":"10.1177","volume":"33","author":[{"given":"Jeffrey","family":"Berger","sequence":"first","affiliation":[{"name":"Divisions of Palliative Medicine and Geriatrics, Winthrop University Hospital, Mineola, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Lester","sequence":"additional","affiliation":[{"name":"Divisions of Geriatrics and Palliative Medicine, Winthrop University Hospital, Mineola, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucan","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Division of Palliative Care, Flushing Hospital, Flushing, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"bibr1-1049909115569047","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2004.01.007"},{"issue":"5","key":"bibr2-1049909115569047","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0885-3924(98)00096-7","volume":"16","author":"Mercadante S","year":"1998","journal-title":"J Pain Symptom Manage"},{"key":"bibr3-1049909115569047","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/oso\/9780195102444.003.0008","volume-title":"Topics in Palliative Care","author":"Mercadante S","year":"1997"},{"key":"bibr4-1049909115569047","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2014.0176"},{"key":"bibr5-1049909115569047","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.78a.10052"},{"key":"bibr6-1049909115569047","unstructured":"Katzung BG. Basic and Clinical Pharmacology. 8th ed. New York, NY: Lange Medical Books\/McGraw-Hill; 2001:278."},{"key":"bibr7-1049909115569047","unstructured":"Aurobindo Pharma Limited; 2011. www.drugs.com\/pro\/ondansetron.html. Accessed May 2013. Updated January 14, 2015."},{"key":"bibr8-1049909115569047","doi-asserted-by":"publisher","DOI":"10.1177\/014860718701100149"}],"container-title":["American Journal of Hospice and Palliative Medicine\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909115569047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1049909115569047","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909115569047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:29:30Z","timestamp":1777368570000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1049909115569047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1177\/1049909115569047"],"URL":"https:\/\/doi.org\/10.1177\/1049909115569047","relation":{},"ISSN":["1049-9091","1938-2715"],"issn-type":[{"value":"1049-9091","type":"print"},{"value":"1938-2715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]}}}