{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:50:09Z","timestamp":1792702209270,"version":"4.5.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>\n                    Delirium is a palliative care emergency where patients experience changes in perception, awareness, and behavior. Common features include changes in the sleep\u2013wake cycle, emotional lability, delusional thinking, and language and thought disorders. Delirium results from neurotransmitter imbalances involving several neurotransmitters such as dopamine, glutamate, norepinephrine, acetylcholine, gamma-aminobutyric acid, and serotonin. Untreated delirium causes significant morbidity and mortality. Nonpharmacologic and pharmacologic approaches treat delirium. Current pharmacologic management of delirium involves using agents such as haloperidol or second-generation antipsychotics. Third-generation atypical antipsychotic drugs have emerged as a potential choice for delirium management. Aripiprazole is a third-generation antipsychotic with a dopamine receptor-binding profile distinct from other second-generation antipsychotics. Aripiprazole acts as partial agonist at dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    and 5-hydroxytryptamine (5-HT)\n                    <jats:sub>1A<\/jats:sub>\n                    receptors, stabilizing the dopamine receptor leading to improvement in symptoms. The article reviews the pharmacology, pharmacodynamics, metabolism, and evidence of clinical efficacy for this new antipsychotic agent. This article explores possible roles in palliative care.\n                  <\/jats:p>","DOI":"10.1177\/1049909115612800","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T22:09:48Z","timestamp":1448057388000},"page":"180-185","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Aripiprazole"],"prefix":"10.1177","volume":"34","author":[{"given":"Eric","family":"Prommer","sequence":"first","affiliation":[{"name":"Greater Los Angeles Healthcare, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"bibr1-1049909115612800","first-page":"445","volume-title":"Textbook of Neuropsychiatric and Clinical Psychiatry","author":"Trzepacz PT","year":"1997"},{"key":"bibr2-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afm094"},{"key":"bibr3-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2006.9.422"},{"key":"bibr4-1049909115612800","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v02n0103"},{"key":"bibr5-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199304000-00007"},{"key":"bibr6-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2117-0"},{"key":"bibr7-1049909115612800","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v05n0504"},{"key":"bibr8-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106067765"},{"key":"bibr9-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/60.23.2437"},{"key":"bibr10-1049909115612800","unstructured":"Salama P, Meunier J-F, Lafreniere J, Process for the preparation of carbostyril derivatives, such as aripiprazole and its intermediates. U.S. Patent Application, 10\/555,485. 2 8, 2007."},{"key":"bibr11-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300203"},{"key":"bibr12-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(97)00112-7"},{"issue":"19","key":"bibr13-1049909115612800","first-page":"6","volume":"64","author":"Stahl SM","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"bibr14-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1177\/1049909111423094"},{"key":"bibr15-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.033175"},{"issue":"1","key":"bibr16-1049909115612800","first-page":"9","volume":"6","author":"Bandelow B","year":"2003","journal-title":"Ger J Psychiatry"},{"key":"bibr17-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(02)80412-6"},{"key":"bibr18-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.5.3.297"},{"key":"bibr19-1049909115612800","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847070-00004"},{"key":"bibr20-1049909115612800","doi-asserted-by":"publisher","DOI":"10.2165\/11208400-000000000-00000"},{"key":"bibr21-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(03)92073-6"},{"key":"bibr22-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003261901"},{"key":"bibr23-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(00)80351-X"},{"key":"bibr24-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000249944.42859.bf"},{"key":"bibr25-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90066-5"},{"key":"bibr26-1049909115612800","unstructured":"Abilify (aripiprazole) [package insert]. Princeton, NJ: Bristol-Meyers Squibb; 2003, 2013."},{"key":"bibr27-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.07.010"},{"key":"bibr28-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-977715"},{"key":"bibr29-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004269870"},{"key":"bibr30-1049909115612800","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0604"},{"key":"bibr31-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318221e63b"},{"key":"bibr32-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000213"},{"key":"bibr33-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181b675ba"},{"key":"bibr34-1049909115612800","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n1210"},{"key":"bibr35-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(97)88746-9"},{"key":"bibr36-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.7.681"},{"key":"bibr37-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1177\/0269881107081559"},{"key":"bibr38-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.03.031"},{"key":"bibr39-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-200411000-00007"},{"key":"bibr40-1049909115612800","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0903"},{"key":"bibr41-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3182491e29"},{"key":"bibr42-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181b3b379"},{"issue":"6","key":"bibr43-1049909115612800","first-page":"642","volume":"43","author":"Babu KM","year":"2005","journal-title":"Clin Toxicol"},{"key":"bibr44-1049909115612800","volume-title":"Title 21 CFR 201.56. Requirements on content and format of labeling for human prescription drug and biological products","author":"Department of Health and Human Services","year":"2012"},{"key":"bibr45-1049909115612800","unstructured":"Department of Health and Human Services, Food and Drug Administration Title 21 CFR 201.57-Specific requirements on content and format of labeling for human prescription drug and biological products described in Sec.\n                      201.56(b)(1)\n                      , 2012. Silver Spring, MD: Department of Health and Human Services, Food and Drug Administration; 2014."},{"key":"bibr46-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951511000368"},{"key":"bibr47-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3181557b47"},{"key":"bibr48-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000178415.22309.8f"},{"issue":"2","key":"bibr49-1049909115612800","first-page":"CD004578","author":"El-Sayeh HG","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr50-1049909115612800","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v68n0604"},{"key":"bibr51-1049909115612800","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06541"},{"key":"bibr52-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1651"},{"key":"bibr53-1049909115612800","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000248620.34541.bc"}],"container-title":["American Journal of Hospice and Palliative Medicine\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909115612800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1049909115612800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909115612800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:29:54Z","timestamp":1777368594000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1049909115612800"}},"subtitle":["A New Option in Delirium"],"short-title":[],"issued":{"date-parts":[[2016,7,10]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/1049909115612800"],"URL":"https:\/\/doi.org\/10.1177\/1049909115612800","relation":{},"ISSN":["1049-9091","1938-2715"],"issn-type":[{"value":"1049-9091","type":"print"},{"value":"1938-2715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,10]]}}}