{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:44:56Z","timestamp":1777383896283,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI","doi-asserted-by":"crossref","award":["Grant Number 25293165"],"award-info":[{"award-number":["Grant Number 25293165"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Few data are available on bereaved family members\u2019 perspective on the frequency of symptoms and degree of distress among terminal patients with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We sent a questionnaire to 1472 bereaved family members of terminal patients with cancer in 20 general hospitals. The questionnaire asked them (1) to indicate which symptoms the patients had, (2) to rate on a 4-point scale the extent to which the symptom was distressing, as follows: 1 = not distressing, 2 = slightly distressing, 3 = quite distressing, and 4 = very distressing at the point of 2 weeks before the patient had died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We analyzed 805 questionnaires for this study. Anorexia was the commonest symptom among terminal patients with cancer experienced by bereaved family members, followed by somnolence, weight loss, fatigue, and pain. Anorexia was the most distressing symptom among terminal patients with cancer experienced by bereaved family members, followed by weight loss, pain, edema, and dyspnea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Anorexia and weight loss were frequent symptoms and bereaved family members felt very distressing. Furthermore, there are not means of effective treatment now. Thus, we think that further study in this field is necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1049909118765409","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T22:46:51Z","timestamp":1522709211000},"page":"972-977","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Bereaved Family Members\u2019 Perceptions of the Distressing Symptoms of Terminal Patients With Cancer"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9229-176X","authenticated-orcid":false,"given":"Yoshiaki","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy Education, Osaka University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Morita","sequence":"additional","affiliation":[{"name":"Pallaitive and Supportive Care devision, Seirei Mikatahara General Hospital, Hamamatsu, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Tsuneto","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Kyoto University Hospital, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maho","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kizawa","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Kobe University School of Medicine, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Tsukuba Medical Center Hospital, Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunori","family":"Miyashita","sequence":"additional","affiliation":[{"name":"Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"bibr1-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6746.277"},{"key":"bibr2-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-199402000-00006"},{"key":"bibr3-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00437-8"},{"key":"bibr4-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1191\/026921698676629560"},{"key":"bibr5-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1177\/082585979801400306"},{"key":"bibr6-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(02)00011-4"},{"key":"bibr7-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1177\/082585970402000105"},{"key":"bibr8-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2006.10.015"},{"key":"bibr9-1049909118765409","doi-asserted-by":"publisher","DOI":"10.2512\/jspm.11.254"},{"key":"bibr10-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1177\/1049909116646336"},{"key":"bibr11-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70040-2"},{"key":"bibr12-1049909118765409","unstructured":"National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Palliative Care, Version 2.2017. https:\/\/www.nccn.org\/professionals\/physician_gls\/f_guidelines.asp#supportive. Accessed March 8, 2018."},{"key":"bibr13-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds233"},{"key":"bibr14-1049909118765409","unstructured":"World Health Organization. Treatment Guidelines on Pain, 8 2017. http:\/\/www.who.int\/medicines\/areas\/quality_safety\/guide_on_pain\/en\/. Accessed March 8, 2018."},{"key":"bibr15-1049909118765409","volume-title":"Textbook of Palliative Medicine and Supportive Care","author":"Bruera E","year":"2016","edition":"2"},{"key":"bibr16-1049909118765409","unstructured":"Twycross R, Wilcock A, Howard P. Palliative Care Formulary (PCF5). Palliativedrugs.com Ltd, Nottingham, http:\/\/www.palliativedrugs.com\/assets\/pcf5\/PCF5_sample_prelims.pdf Accessed March 8, 2018."},{"key":"bibr17-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1177\/1049909108315517"},{"key":"bibr18-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.01.007"},{"key":"bibr19-1049909118765409","unstructured":"Japan Hospice Palliative Care Foundation. http:\/\/www.hpcj.org\/ Accessed March 15, 2018."},{"key":"bibr20-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.107"},{"key":"bibr21-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)90182-1"},{"key":"bibr22-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1177\/0148607108325076"},{"key":"bibr23-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"bibr24-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(03)00074-5"},{"key":"bibr25-1049909118765409","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000901)89:5<1162::AID-CNCR26>3.0.CO;2-Y"}],"container-title":["American Journal of Hospice and Palliative Medicine\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909118765409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1049909118765409","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1049909118765409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:27:47Z","timestamp":1777368467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1049909118765409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,2]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1177\/1049909118765409"],"URL":"https:\/\/doi.org\/10.1177\/1049909118765409","relation":{},"ISSN":["1049-9091","1938-2715"],"issn-type":[{"value":"1049-9091","type":"print"},{"value":"1938-2715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,2]]}}}