{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:52:25Z","timestamp":1777384345636,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Context: Methylnaltrexone is a peripherally-acting mu-opioid receptor antagonist studied in both cancer and non-cancer patients with opioid-induced constipation (OIC), but mostly in the outpatient setting. For adult hospitalized cancer patients with OIC, its effectiveness is unknown. Objectives: Describe the efficacy of methylnaltrexone for OIC in the inpatient setting, defined as bowel movement (BM) within 24\u00a0hours of methylnaltrexone administration. Methods: We performed a single-center, retrospective chart review of all hospitalized, adult patients with a cancer diagnosis who received methylnaltrexone from the palliative care team between January 1st, 2012 and July 1st, 2019. Results: We identified 194 patients. The mean age was 59, 50.5% were male and 88% were white. 192 patients (98%) received the 8\u00a0mg dose subcutaneously. The median oral morphine equivalent (OME) was 135\u00a0mg (IQR 70-354\u00a0mg). 45% (95% confidence interval, 38-53%) had a BM within 24\u00a0hours. Higher OME was correlated with successful BM, with a response in 93% (86\/92) of patients receiving \u2265150 OME and 2% (2\/102) of patients receiving &lt;150 OME ( P &lt; .0001). Prior laxative use did not predict response at 24\u00a0hours whether these were osmotic laxatives (40.7% vs 47.1%, P = .52), stimulant laxatives (45.7% vs 45.2%, P &gt; .99), or stool softeners (44.7% vs 46.1%, P = .89). Conclusion: Methylnaltrexone has a high response rate when used as treatment for OIC in hospitalized adult cancer patients, especially for patients taking \u2265150 OME.<\/jats:p>","DOI":"10.1177\/10499091221147903","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T07:26:10Z","timestamp":1671866770000},"page":"1093-1097","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Response Rates to Methylnaltrexone in Hospitalized Cancer Patients"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-0466","authenticated-orcid":false,"given":"David","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kalir","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Dobbie","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flannery","family":"Fielding","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Lagman","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahed","family":"Makhoul","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-6791","authenticated-orcid":false,"given":"Susan","family":"McInnes","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Supportive and Palliative Care, Baylor Scott and White Health, Dallas, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Neale","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Rybicki","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Robbins-Ong","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Neuendorf","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,12,24]]},"reference":[{"key":"bibr1-10499091221147903","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.0038"},{"key":"bibr2-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.02.009"},{"key":"bibr3-10499091221147903","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2013.851082"},{"key":"bibr4-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618786145"},{"key":"bibr5-10499091221147903","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2009.0014"},{"key":"bibr6-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.016"},{"key":"bibr7-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2299(200006)50:2<133::AID-DDR1>3.0.CO;2-8"},{"key":"bibr8-10499091221147903","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S88203"},{"key":"bibr9-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.3.367"},{"key":"bibr10-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707377"},{"key":"bibr11-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05913-6"},{"key":"bibr12-10499091221147903","doi-asserted-by":"publisher","DOI":"10.3109\/21556660.2013.838169"},{"issue":"1","key":"bibr13-10499091221147903","first-page":"33","volume":"36","author":"Watkins JL","year":"2011","journal-title":"P T"},{"key":"bibr14-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24615"},{"key":"bibr15-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31820d9b76"},{"key":"bibr16-10499091221147903","volume-title":"Demystifying Opioid Conversion Calculations","author":"McPherson M","year":"2010"},{"key":"bibr17-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.02.030"},{"key":"bibr18-10499091221147903","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2018.79809"},{"key":"bibr19-10499091221147903","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.11.001"}],"container-title":["American Journal of Hospice and Palliative Medicine\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10499091221147903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10499091221147903","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10499091221147903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:29:44Z","timestamp":1777368584000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10499091221147903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,24]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/10499091221147903"],"URL":"https:\/\/doi.org\/10.1177\/10499091221147903","relation":{},"ISSN":["1049-9091","1938-2715"],"issn-type":[{"value":"1049-9091","type":"print"},{"value":"1938-2715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,24]]}}}