{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:17:12Z","timestamp":1783124232068,"version":"3.54.6"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T00:00:00Z","timestamp":1753574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to examine the factors associated with potentially inappropriate medication (PIM) use and the deprescribing among home hospice patients in Taipei, Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 101 home hospice patients from a Taipei City hospital from 2016 to 2022, using 2 significant PIMs which are identified by the OncPal guideline and STOPPFrail version 2 respectively. Logistic regression and Cox proportional hazards regression were used to analyze factors associated with PIMs and the deprescribing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 101 participants, about half of the patients were prescribed at least 1 of the 2 PIM at the beginning of the program. 41.6% had excessive polypharmacy and 29.7% received nasogastric tube feeding. The common drug of the both PIMs included antihypertensives, antiulcer agents, vitamins and statins. We found the factor associated with using both PIMs is excessive polypharmacy, with adjusted odds ratios of 5.87 (95% Cl: 2.14-16.08) for STOPPFrail and 10.39 (95% Cl: 3.38-31.99) for OncPal respectively. The discontinuation rate is about 30%. A negative association was found between nasogastric tube feeding and PIM deprescribing, with adjusted hazard ratios of 0.23 (95% Cl: 0.07-0.82) for STOPPFrail and 0.08 (95% Cl: 0.02-0.46) for OncPal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates a high prevalence of PIMs among home-hospice care patients, with PIMs being less likely to be deprescribed in those receiving nasogastric tube feeding. The further research may be warranted to minimize use of PIM to enhance medication safety for patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10499091251361460","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T04:20:45Z","timestamp":1753676445000},"page":"932-939","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Potentially Inappropriate Medication Use and Deprescribing Among Patients Receiving Home-Based Hospice Care"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1946-8407","authenticated-orcid":false,"given":"Yi-Chen","family":"Wu","sequence":"first","affiliation":[{"name":"Taipei City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chang","family":"Yang","sequence":"additional","affiliation":[{"name":"Taipei City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Sui","family":"Lee","sequence":"additional","affiliation":[{"name":"The Department of Dermatology, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Feng","family":"Yen","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Taipei City Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Taipei City Hospital"},{"name":"National Yang-Ming Chiao Tung University and National Taipei University of Nursing and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,27]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18372"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-022-00679-w"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2322-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa159"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12400"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.24304\/kjcp.2021.31.1.1"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010505"},{"key":"e_1_3_4_9_2","unstructured":"Diabetes UK. End of life guidance for diabetes care. https:\/\/www.diabetes.org.uk\/professionals\/position-statements-reports\/diagnosis-ongoing-management-monitoring\/end-of-life-care. Accessed 7 January 2024."},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13874"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2021.07.009"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04010.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1684"},{"key":"e_1_3_4_14_2","first-page":"63","article-title":"An implementation for improving the safety of medication for older emergency department patients waiting for bed and reducing major polypharmacy and potentially inappropriate medications","volume":"6","author":"Liu YL","year":"2021","unstructured":"Liu YL, Chu LL, Wu PC, et al. An implementation for improving the safety of medication for older emergency department patients waiting for bed and reducing major polypharmacy and potentially inappropriate medications. 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