{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:42:31Z","timestamp":1792485751095,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early-onset Alzheimer\u2019s disease is a rapidly progressing condition that severely disrupts quality of life. Early palliative care incorporation helps identify patients\u2019 needs and facilitates family decision-making and advanced care planning for later stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The study aimed to assess palliative care needs, level of suffering, and most frequent symptoms in Early-onset Alzheimer\u2019s patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We present a preliminary observational analysis as part of a larger, 18-month longitudinal study of patients with early-onset Alzheimer\u2019s disease. Patients with the PSEN1-E280\u00a0A variant of Early-onset Alzheimer\u2019s disease attending the Antioquia Neuroscience Group at the University of Antioquia in Medell\u00edn, Colombia, participated. Data were collected using NECPAL, Edmonton Symptom Assessment System Revised, Global Deterioration Scale\/Functional Assessment Staging (GDS\/FAST), Pain Assessment in Advanced Dementia (PAINAD), and a numeric rating scale. Regarding data analyses from visit 1 (V1), variables were described according to their nature. A Poisson regression was performed, and prevalence ratios, 95% confidence intervals, and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values were obtained. Statistical significance was defined with an alpha value of 5%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-six patients participated in V1. Median age was 53. Most of them were women and lived in urban areas. The prevalence of palliative care needs was 22.22%. Poisson regression showed an association between clinician-perceived need for palliative care and dysphagia, pressure ulcers, asthenia, insomnia, functional decline, resource utilization, positive surprise question in NECPAL instrument, and scores of the PAINAD and GDS\/FAST scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with Early-onset Alzheimer\u2019s have palliative care needs associated with symptoms related to disease progression, prognosis, resource utilization, and pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10499091251393485","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:51:10Z","timestamp":1761601870000},"page":"1346-1354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Palliative Care Needs in Patients With Early-Onset Alzheimer\u2019s Disease: A Cross-Sectional Report"],"prefix":"10.1177","volume":"43","author":[{"given":"Mar\u00eda Alejandra","family":"Tabares-Villamizar","sequence":"first","affiliation":[{"name":"Universidad Pontificia Bolivariana"},{"name":"Universidad Pontificia Bolivariana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gallo-Henao","sequence":"additional","affiliation":[{"name":"Universidad Pontificia Bolivariana"},{"name":"Universidad Pontificia Bolivariana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Londo\u00f1o","sequence":"additional","affiliation":[{"name":"Universidad Pontificia Bolivariana"},{"name":"Universidad Pontificia Bolivariana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"M\u00e1rquez-Lugo","sequence":"additional","affiliation":[{"name":"University of 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