{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:23:28Z","timestamp":1778826208593,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Polypharmacy and potentially inappropriate medications (PIMs) are common among end-of-life older adults and may cause harm while offering limited benefit. Evidence from Asia remains scarce. This study aimed to determine the prevalence of polypharmacy and PIMs, and to identify associated factors using the Screening Tool of Older Persons\u2019 Prescriptions in Frail adults with limited life expectancy (STOPPFrail) version 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross-sectional chart review of patients aged \u226560\u00a0years referred to the Palliative Care Unit at Thammasat University Hospital, Thailand, between January and December 2021. Polypharmacy was defined as the concurrent use of \u22655 medications. PIMs were identified using STOPPFrail version 2. Logistic regression was applied to examine associations between demographic and clinical variables and polypharmacy or PIM use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 384 patients screened, 244 met inclusion criteria. The mean age was 75.7\u00a0years, and 51.2% were male. Polypharmacy was observed in 82.8%, while 93.7% received at least one PIM. Factors significantly associated with polypharmacy included hospital stay \u226511 days (OR 2.43, 95% CI 1.12-5.29,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .025) and a higher number of symptoms (OR 1.61, 95% CI 1.00-2.58,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .048). PIM use was associated with a Palliative Performance Scale of 30% (OR 6.23, 95% CI 1.13-34.47,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .036) and polypharmacy (OR 17.95, 95% CI 4.42-72.99,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Polypharmacy and PIMs are highly prevalent among end-of-life older adults in Thailand. These results highlight the need for systematic medication review and deprescribing strategies, supported by multidisciplinary teams, to reduce medication burden and improve patient-centered palliative care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10499091251395058","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T16:43:41Z","timestamp":1762015421000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Polypharmacy and Potentially Inappropriate Medications at the End of Life: Prevalence, Predictors, and Deprescribing Implications From a STOPPFrail Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2502-1123","authenticated-orcid":false,"given":"Natakamol","family":"Pumsuwan","sequence":"first","affiliation":[{"name":"Thammasat University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4802-2271","authenticated-orcid":false,"given":"Ruankwan","family":"Kanhasing","sequence":"additional","affiliation":[{"name":"Thammasat University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-2331","authenticated-orcid":false,"given":"Wadee","family":"Wongpradit","sequence":"additional","affiliation":[{"name":"Thammasat University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Social Development: Ageing Societies","author":"UNESCAP","year":"2021","unstructured":"UNESCAP. Social Development: Ageing Societies. New York: UN; 2021. [cited 2022 Jul 16]. Available from:. https:\/\/www.unescap.org\/our-work\/social-development\/ageing-societies"},{"key":"e_1_3_5_3_2","volume-title":"Situation of the Thai Older Persons 2023","author":"Department of Older Persons","year":"2024","unstructured":"Department of Older Persons. Situation of the Thai Older Persons 2023. Bangkok: Department of Older Persons, Ministry of Social Development and Human Security; 2024. Available from:. https:\/\/www.dop.go.th\/download\/statistics\/th1738230377-2563_1.pdf"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1596\/35693"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.18356\/6a8968ef-en"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.02.028"},{"key":"e_1_3_5_7_2","unstructured":"Pongboriboon U. The elderly situation in Thailand: health\u2019s problems and needs. 2020;12(2): 46-58."},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2018.06.018"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199835010-00004"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2055-2335.2011.tb00684.x"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.09.003"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02649-6"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-019-00717-1"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000558316.40245.ca"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2015-000941"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2098-7"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2322-0"},{"key":"e_1_3_5_18_2","volume-title":"Palliative and End-of-Life Care Handbook (for Healthcare Professionals) [Internet]","author":"Siraprapasiri P","year":"2020","unstructured":"Siraprapasiri P. Introduction. In: Palliative and End-of-Life Care Handbook (for Healthcare Professionals) [Internet], 1. Bangkok: War Veterans Organization of Thailand Under Royal Patronage; 2020. [25-32 (in Thai)]. 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