{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:30:55Z","timestamp":1790400655297,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Ketamine is used to treat refractory cancer pain, but evidence for analgesic and opioid-sparing benefits remains mixed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study assessed the efficacy and tolerability of ketamine continuous infusion (CI) for cancer pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis assessed adult patients admitted to an academic health system between October 2022 and December 2024, who received at least 48\u00a0hours of ketamine CI initiated by the palliative team for pain. Data included ketamine dose, morphine equivalent daily dose (MEDD), numerical pain score (NPS), and mean arterial pressure (MAP) throughout ketamine infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      34 met the inclusion criteria. Median age was 52.5\u00a0years, 53 percent were female, and 79 percent had a solid tumor. Baseline median NPS was 8\/10. Ketamine CI was initiated at a median rate of 0.1\u00a0mg\/kg\/hr (mean 0.12, SD 0.04) and titrated to a median maximum of 0.2\u00a0mg\/kg\/hr (mean 0.21, SD 0.10). At 48\u00a0hours, the mean paired NPS reduction was 1.4 points (95% CI, 0.5 to 2.4;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .004). By final infusion day (paired n = 28), the mean reduction was 1.9 points (95 percent CI -2.8 to \u22121.0;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). MEDD remained stable from baseline (mean 360, SD 371) through the final day (mean 350, SD 356), and MAP was stable across the first 48\u00a0hours. No psychoactive adverse effects were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ketamine CI produced a statistically significant and clinically meaningful reduction in cancer pain that increased over the course of infusion and was tolerated without identified psychoactive or circulatory adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10499091261452628","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:04:54Z","timestamp":1778767494000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective Chart Review Evaluating Efficacy and Tolerability of Ketamine Continuous Infusion for Cancer-Related Pain"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-8693","authenticated-orcid":false,"given":"Rabia S.","family":"Atayee","sequence":"first","affiliation":[{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashal","family":"Hasan","sequence":"additional","affiliation":[{"name":"UC San Diego Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahfreen","family":"Alam","sequence":"additional","affiliation":[{"name":"UC San Diego Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-5211","authenticated-orcid":false,"given":"Kyle P.","family":"Edmonds","sequence":"additional","affiliation":[{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-6381","authenticated-orcid":false,"given":"Jamie","family":"Kneebusch","sequence":"additional","affiliation":[{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toluwalase A.","family":"Ajayi","sequence":"additional","affiliation":[{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"},{"name":"UC San Diego Health Sciences"},{"name":"Rady Children\u2019s Hospital & Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1439"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01310-0"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.1081"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.15386\/cjmed-500"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2023.11.004"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2018.0627"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14228"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000808"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2005.8.49"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/082585971002600306"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S217005"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2015.04.005"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.12.330"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.20472"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00349-9"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003351.pub3"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.015198"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0383-6"},{"issue":"6","key":"e_1_3_5_20_2","first-page":"555","article-title":"Ketamine protocol for palliative care in cancer patients with refractory pain","volume":"6","author":"Loveday BA","year":"2015","unstructured":"Loveday BA, Sindt J. Ketamine protocol for palliative care in cancer patients with refractory pain. 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