{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:46:08Z","timestamp":1785703568466,"version":"3.56.0"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Am J Hosp Palliat Care"],"abstract":"\n Purpose<\/jats:title>\n Metastatic spinal cord compression (MSCC) is a debilitating complication of advanced malignancies, associated with immense physical and emotional distress. The aim of this study was to assess the trajectory of emotional well-being (primary outcome) and quality of life (QoL), functional status, and pain (secondary outcomes) over 30 days.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n 106 MSCC patients were included in this prospective observational study. Assessments were done using the Hospital Anxiety and Depression Scale (HADS) for emotional well-being, EORTC QLQ-C30 for QoL, Karnofsky Performance Status (KPS) for functional status, and the numeric rating scale (NRS) for pain. These were conducted at baseline (\n T<\/jats:italic>\n \n 0<\/jats:italic>\n <\/jats:sub>\n ), day 10 (\n T<\/jats:italic>\n \n 10<\/jats:italic>\n <\/jats:sub>\n ), and day 30 (\n T<\/jats:italic>\n \n 30<\/jats:italic>\n <\/jats:sub>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean age of the participants was 54.1 years. A V-shaped pattern was observed in emotional well-being; improvement in HADS was noted from\n T<\/jats:italic>\n \n 0<\/jats:italic>\n <\/jats:sub>\n to\n T<\/jats:italic>\n \n 10<\/jats:italic>\n <\/jats:sub>\n (\n P<\/jats:italic>\n < 0.001), but they worsened by\n T<\/jats:italic>\n \n 30<\/jats:italic>\n <\/jats:sub>\n (\n P<\/jats:italic>\n < 0.01). Global health and functional domains of QoL (\n P<\/jats:italic>\n < 0.05) showed improvement, but these gains plateaued as fatigue and financial distress increased. Baseline correlation weakened over time between QoL and functional domains. At\n T<\/jats:italic>\n \n 30<\/jats:italic>\n <\/jats:sub>\n , the only domain that remained significantly associated with QoL was emotional functioning, underscoring its strong link to overall QoL. The pain decreased significantly by day 10.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n MSCC affects the emotional well-being and QoL. Initial improvements in psychological symptoms is followed by an eventual decline. There is a paradox wherein, despite objective health deterioration there is subjective improvement in well-being. Hence, a multidisciplinary approach, involving psychological and rehabilitative support, becomes crucial for optimal patient-centred care.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10499091261475299","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:22:33Z","timestamp":1785464553000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Trajectories of Emotional Well-Being and Quality of Life in Patients Presenting With Metastatic Spinal Cord Compression: A Prospective Observational Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2870-3220","authenticated-orcid":false,"given":"Anjali P","family":"Govind","sequence":"first","affiliation":[{"name":"Dr BRA IRCH"},{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-903X","authenticated-orcid":false,"given":"Anuja","family":"Pandit","sequence":"additional","affiliation":[{"name":"National Cancer Institute"},{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Sirohiya","sequence":"additional","affiliation":[{"name":"National Cancer Institute"},{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev Kumar","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Dr BRA IRCH"},{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2097-7180","authenticated-orcid":false,"given":"Sushma","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Critical Care, Pain Management, and Palliative Care, Max Saket"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Mishra","sequence":"additional","affiliation":[{"name":"Dr BRA IRCH"},{"name":"All India Institute of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.1211"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12817"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17091479"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.105555"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1758846"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2022.100446"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.p1973"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2006.11.010"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/os.12253"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2022.05.017"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102942"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.86049"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-08186-4"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00602-3"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/clon.2002.0098"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01709-7"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2019.28.17.S24"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.12968\/ijpn.2016.22.1.37"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2008.0231"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_3_6_22_2","unstructured":"Scott N Fayers P Aaronson N Bottomley A de Graeff A Groenvold M Gundy C Koller M Petersen MA Sprangers MA. 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